3-(3-Pyridinylcarbonyl-D4)-1-(trimethylsilyl)-2-pyrrolidinone

CAS: 53844-42-1

Ref. TR-P991922

Informação sobre produto

• Nome: 3-(3-Pyridinylcarbonyl-D4)-1-(trimethylsilyl)-2-pyrrolidinone
• Sinónimos: 3-(2,4,5,6-tetradeuteriopyridine-3-carbonyl)-1-trimethylsilylpyrrolidin-2-one

Descrição

Applications 3-(3-Pyridinylcarbonyl-D4)-1-(trimethylsilyl)-2-pyrrolidinone is an intermediate in the synthesis of (S)-(-)-Nicotine-d4 (N412452). Labelled analogue of (S)-(-)-Nicotine, a prototype nicotinic acetylcholine receptor agonist. (S)-(-)-Nicotine is the naturally occurring isomer. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.
References Geffken, D. et al.: Am. J. Epidemiol., 153, 242 (2001); Bolego, C. et al.: Cardiovasc. Res., 53, 568 (2002); Leone, A. et al.: Curr. Pharm. Des., 1, 2199 (2005);

• Marca: TRC

Propriedades químicas

• Peso molecular: 266.404
• Fórmula: C₁₃D₄H₁₄N₂O₂Si
• Cor/forma: Neat
• InChI: InChI=1S/C13H18N2O2Si/c1-18(2,3)15-8-6-11(13(15)17)12(16)10-5-4-7-14-9-10/h4-5,7,9,11H,6,8H2,1-3H3/i4D,5D,7D,9D
• Chave InChI: InChIKey=YUXKQUSKBHLIHI-PTRQDKBOSA-N
• SMILES: [2H]c1nc([2H])c(C(=O)C2CCN([Si](C)(C)C)C2=O)c([2H])c1[2H]