SU 5416

CAS: 204005-46-9

Ref. TR-S688030

Informação sobre produto

• Nome: SU 5416
• Sinónimos: (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one, (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one, (Z)-3-(3,5-Dimethylpyrrol-2-ylmethylene)indolin-2-one, 2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-, 3-((2,4-Dimethylpyrrol-5-YL)METHYLIDENYL)-2-indolonone, 3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydroindol-2-one, 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one, 3-[(3,5-Dimethylpyrrol-2-yl)methylene]indolin-2-one, Nsc-696819, Semaxanib, Semaxinib, Semoxind, Su-5416, Sugen 5416, Tsu-16, VEGFR2 receptor tyrosine kinase III
• CAS: 204005-46-9

Descrição

Applications SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into tumor tissues.
References Mizuno, S. et al.: Am. J. Respir. Cell. Mol. Biol., 47, 679 (2012)); Yoshizawa, Y. et al.: Mol. Pharm., 9, 3486 (2012);

• Marca: TRC

Propriedades químicas

• Peso molecular: 238.28
• Fórmula: C₁₅H₁₄N₂O
• Cor/forma: Neat
• InChI: InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
• Chave InChI: InChIKey=WUWDLXZGHZSWQZ-WQLSENKSSA-N
• SMILES: Cc1cc(C)c(/C=C2\C(=O)Nc3ccccc32)[nH]1