TAE 684

CAS: 761439-42-3

Ref. TR-T004600

Informação sobre produto

• Nome: TAE 684
• Sinónimos: 5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine, AE 684, NVP-TAE 684, NVT TAE-684, 2,4-Pyrimidinediamine, 5-chloro-N²-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N⁴-[2-[(1-methylethyl)sulfonyl]phenyl]-, 5-Chloro-N²-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N⁴-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine, Ae 684, Nvp-Tae 684, Nvp-Tae684-Tae 684, Nvt Tae-684, Tae 684, Tae684(Nvp-Tae684)
• CAS: 761439-42-3

Descrição

Applications TAE 684 is a potent, selective, and efficacious inhibitor of NPM-ALK, a fusion protein that is a key regulator of oncogenic events that drives the survival and proliferation of anaplastic large-cell lymphomas. Potent ALK inhibitor
References Schoenherr, C., et al.: Oncogene., 31, 5193 (2012); Tanizaki, J., et al.: Clin. Cancer. Res., 18, 6219 (2012); Heuckmann, J.M., et al.: Clin. Cancer. Res., 18, 4682 (2012);

• Marca: TRC

Propriedades químicas

• Peso molecular: 614.20
• Fórmula: C₃₀H₄₀ClN₇O₃S
• Cor/forma: Neat
• InChI: InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)