3a,4,5,6-Tetrahydro-1H,3H-naphtho[1,8-cd]pyran-1-one

CAS: 81603-30-7

Ref. TR-T294795

Informação sobre produto

• Nome: 3a,4,5,6-Tetrahydro-1H,3H-naphtho[1,8-cd]pyran-1-one
• Marca: TRC
• Descrição: Applications 3a,4,5,6-Tetrahydro-1H,3H-naphtho[1,8-cd]pyran-1-one is an intermediate in the synthesis of (S,S)-Palonosetron Acid which is an impurity in the synthesis of (S,S) Palonosetron (P165800), serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),

Propriedades químicas

• Peso molecular: 188.22
• Fórmula: C₁₂H₁₂O₂
• Cor/forma: Neat
• InChI: InChI=1S/C12H12O2/c13-12-10-6-2-4-8-3-1-5-9(7-14-12)11(8)10/h2,4,6,9H,1,3,5,7H2
• Chave InChI: InChIKey=LSEVFEBTWFXXKS-UHFFFAOYSA-N
• SMILES: O=C1OCC2CCCc3cccc1c32