Thiazol-5-ylmethyl ((2R,5R)-5-Amino-1,6-diphenylhexan-2-yl)carbamate Hydrochloride

CAS: 1247119-33-0

Ref. TR-T344296

Informação sobre produto

• Nome: Thiazol-5-ylmethyl ((2R,5R)-5-Amino-1,6-diphenylhexan-2-yl)carbamate Hydrochloride
• Sinónimos: Carbamic acid, N-[(1R,4R)-4-amino-5-phenyl-1-(phenylmethyl)pentyl]-, 5-thiazolylmethyl ester, hydrochloride (1:1), Thiazol-5-ylmethyl N-((1R,4R)-4-Amino-1-benzyl-5-phenylpentyl)carbamate Hydrochloride, Carbamic acid, N-[(1R,4R)-4-amino-5-phenyl-1-(phenylmethyl)pentyl]-, 5-thiazolylmethyl ester, hydrochloride (1:1), Thiazol-5-ylmethyl (2R,5R)-5-amino-1,6-diphenylhexan-2-ylcarbaMate hydrochloride
• CAS: 1247119-33-0

Descrição

Applications Thiazol-5-ylmethyl ((2R,5R)-5-Amino-1,6-diphenylhexan-2-yl)carbamate Hydrochloride is an impurity of Cobicistat (C633150), a HIV protease inhibitor that has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer.
References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012)

• Marca: TRC

Propriedades químicas

• Peso molecular: 446.0
• Fórmula: C₂₃H₂₇N₃O₂S·HCl
• InChI: InChI=1S/C23H27N3O2S.ClH/c24-20(13-18-7-3-1-4-8-18)11-12-21(14-19-9-5-2-6-10-19)26-23(27)28-16-22-15-25-17-29-22, 1H/t20-,21-, /m1./s1, /h1-10,15,17,20-21H,11-14,16,24H2,(H,26,27)
• Chave InChI: InChIKey=UPZSMWCRMXVNOX-MUCZFFFMSA-N
• SMILES: Cl.N[C@H](CC[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)Cc1ccccc1