7-O-(Triethylsilyl)-2’-O-tert-butyl(dimethyl)silyl Paclitaxel

CAS: 156413-61-5

Ref. TR-T777810

Informação sobre produto

• Nome: 7-O-(Triethylsilyl)-2’-O-tert-butyl(dimethyl)silyl Paclitaxel
• Sinónimos: (αR,βS)-β-(Benzoylamino)-α-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4-[(triethylsilyl)oxy]-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester, Paclitaxel - In House Impurity
• Marca: TRC
• Descrição: Impurity Paclitaxel - In House ImpurityApplications Protected Paclitaxel (P132500). An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. Paclitaxel - In House Impurity.References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),

Propriedades químicas

• Peso molecular: 1082.43
• Fórmula: C₃₈H₅₂O₂₅
• Cor/forma: Neat
• InChI: InChI=1S/C38H52O25/c1-14(39)48-11-24-27(51-16(3)41)30(54-19(6)44)33(56-21(8)46)36(60-24)50-13-26-29(53-18(5)43)32(35-37(61-26)59-23(10)58-35)63-38-34(57-22(9)47)31(55-20(7)45)28(52-17(4)42)25(62-38)12-49-15(2)40/h23-38H,11-13H2,1-10H3/t23?,24?,25?,26?,27-,28+,29-,30?,31?,32?,33?,34?,35?,36+,37+,38+/m0/s1
• Chave InChI: InChIKey=YWTLKYGRDHOVGY-NPFFYKGZSA-N
• SMILES: CC(=O)OCC1O[C@@H](OCC2O[C@H]3OC(C)OC3C(O[C@H]3OC(COC(C)=O)[C@@H](OC(C)=O)C(OC(C)=O)C3OC(C)=O)[C@H]2OC(C)=O)C(OC(C)=O)C(OC(C)=O)[C@H]1OC(C)=O