5-(3,4,5-Trimethoxybenzoyl)-2,4-pyrimidinediamine

CAS: 30806-86-1

Ref. TR-T795855

Informação sobre produto

• Nome: 5-(3,4,5-Trimethoxybenzoyl)-2,4-pyrimidinediamine
• Sinónimos: (2,4-Diaminopyrimidin-5-yl)-(3,4,5-trimethoxyphenyl)methanone, Trimethoprim Imp. B (EP)
• Marca: TRC

Descrição

Stability Hygroscopic
Applications 5-(3,4,5-Trimethoxybenzoyl)-2,4-pyrimidinediamine, is a derivative of Trimethoprim (T795615), an antibacterial agent. 5-(3,4,5-Trimethoxybenzoyl)-2,4-pyrimidinediamine, is a possible potent and selective inhibitor targeting dihydrofolate reductase of C. hominis, used for the treatment of Cryptosporidiosis.
References Popov, V. M., et al.: Bioorg. Med. Chem. Lett., 16, 4366 (2006); Brogden, R.N., et al.: Drugs, 23, 405 (1982);

Propriedades químicas

• Peso molecular: 304.3
• Fórmula: C₁₄H₁₆N₄O₄
• Cor/forma: Neat
• InChI: InChI=1S/C14H16N4O4/c1-20-9-4-7(5-10(21-2)12(9)22-3)11(19)8-6-17-14(16)18-13(8)15/h4-6H,1-3H3,(H4,15,16,17,18)
• Chave InChI: InChIKey=GAAPPIKAFNZRLA-UHFFFAOYSA-N
• SMILES: COc1cc(C(=O)c2cnc(N)nc2N)cc(OC)c1OC