(3α,5β,7α,12α)-3,7,12-Tris(ethoxymethoxy)-cholan-24-ol

Ref. TR-T887900

Informação sobre produto

• Nome: (3α,5β,7α,12α)-3,7,12-Tris(ethoxymethoxy)-cholan-24-ol

Descrição

Applications (3α,5β,7α,12α)-3,7,12-Tris(ethoxymethoxy)-cholan-24-ol is an intermediate in the synthesis of (25R)-3β,7α,12α-Trihydroxy-5-cholestenoic Acid (T795130), which is an oxysterol, an oxidized derivatives of cholesterol (C432501), which may be important in many biological processes, including cholesterol homeostasis, atherosclerosis, sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation,[1] though their roles are poorly understood.
References Schroepfer, G., et al.: Physiol. Rev., 80, 361 (2000); Bjorkhem, I.: J. Clin. Invest., 6, 725(2002); Bjorkhem, I., et al.: Arterio. hromb. Vascul. Biol., 22, 734 (2002)

• Marca: TRC

Propriedades químicas

• Peso molecular: 568.83
• Fórmula: C₃₃H₆₀O₇
• Cor/forma: Neat
• InChI: InChI=1S/C33H60O7/c1-7-35-20-38-25-14-15-32(5)24(17-25)18-29(39-21-36-8-2)31-27-13-12-26(23(4)11-10-16-34)33(27,6)30(19-28(31)32)40-22-37-9-3/h23-31,34H,7-22H2,1-6H3/t23-,24+,25-,26-,27?,28?,29-,30+,31?,32+,33-/m1/s1
• Chave InChI: InChIKey=JXFVXPCOXGBYTB-BICFILNQSA-N
• SMILES: CCOCO[C@H]1CC2C(C3CC[C@H]([C@H](C)CCCO)[C@]31C)[C@H](OCOCC)C[C@@H]1C[C@H](OCOCC)CC[C@]21C