S-(Valeroxymethoxymethyl)-Salubrinal

Ref. TR-V091480

Informação sobre produto

• Nome: S-(Valeroxymethoxymethyl)-Salubrinal
• Sinónimos: [(E)-N'-quinolin-8-yl-N-[2,2,2-trichloro-1-[[(E)-3-phenylprop-2-enoyl]amino]ethyl]carbamimidoyl]sulfanylmethoxymethyl pentanoate
• Marca: TRC
• Descrição: Applications S-(Valeroxymethoxymethyl)-Salubrinal is an analogue of Salubrinal (S100550), a phosphatase inhibitor that protects cells from apoptosis caused by endoplasmic reticulum stress and is now known to induce and facilitate apoptotic death of leukemic cell lines.References Drexler, H.: PLOS ONE, 4, e4161 (2009); Long, K., et al.: Bioorgan. Med. Chem., 15, 3849 (2005)

Propriedades químicas

• Peso molecular: 623.978
• Fórmula: C₂₈H₂₉Cl₃N₄O₄S
• Cor/forma: Neat
• InChI: InChI=1S/C28H29Cl3N4O4S/c1-2-3-14-24(37)39-18-38-19-40-27(33-22-13-7-11-21-12-8-17-32-25(21)22)35-26(28(29,30)31)34-23(36)16-15-20-9-5-4-6-10-20/h4-13,15-17,26H,2-3,14,18-19H2,1H3,(H,33,35)(H,34,36)/b16-15+
• Chave InChI: InChIKey=ZWTJTIFKIUEMGK-FOCLMDBBSA-N
• SMILES: CCCCC(=O)OCOCS/C(=N/c1cccc2cccnc12)NC(NC(=O)/C=C/c1ccccc1)C(Cl)(Cl)Cl