Zankiren

CAS: 138742-43-5

Ref. TR-Z148060

Informação sobre produto

• Nome: Zankiren
• Sinónimos: (αS)-N-[(1S,2R,3S)-1-(Cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-α-[[(2S)-2-[[(4-methyl-1-piperazinyl)sulfonyl]methyl]-1-oxo-3-phenylpropyl]amino]-4-thiazolepropanamide, [1S-[1R*[R*(R*)],2S*,3R*]]- N-[1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-α-[[2-[[(4-methyl-1-piperazinyl)sulfonyl]methyl]-1-oxo-3-phenylpropyl]amino]-4-thiazolepropanamide, (S)-N-[(1S,2R,3S)-1-(Cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-α-[(αS)-α-[[(4-methyl-1-piperazinyl)sulfonyl]methyl]hydrocinnamamido]-4-thiazolepropionamide, A 72517, zankiren HCl, N~2~-{(2S)-2-benzyl-3-[(4-methylpiperazin-1-yl)sulfonyl]propanoyl}-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-3-(1,3-thiazol-4-yl)alaninamide, N~2~-{(2S)-2-benzyl-3-[(4-methylpiperazin-1-yl)sulfonyl]propanoyl}-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-3-(1,3-thiazol-4-yl)-L-alaninamide

Descrição

Applications Zankiren, is a drug that acts as a renin inhibitor in human. It has been also shown to be orally active in the dog and other animals.
References Wessale, J. L., et al.: American J. Hypertension, 6, 514 (1993);

• Marca: TRC

Propriedades químicas

• Peso molecular: 705.971
• Fórmula: C₃₅H₅₅N₅O₆S₂
• Cor/forma: Neat
• InChI: InChI=1S/C35H55N5O6S2/c1-25(2)18-32(41)33(42)30(20-27-12-8-5-9-13-27)37-35(44)31(21-29-22-47-24-36-29)38-34(43)28(19-26-10-6-4-7-11-26)23-48(45,46)40-16-14-39(3)15-17-40/h4,6-7,10-11,22,24-25,27-28,30-33,41-42H,5,8-9,12-21,23H2,1-3H3,(H,37,44)(H,38,43)/t2
• Chave InChI: InChIKey=YFDSDRDMDDGDFC-HOQQKOLYSA-N
• SMILES: CC(C)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cscn1)NC(=O)[C@H](Cc1ccccc1)CS(=O)(=O)N1CCN(C)CC1