CAS 100007-53-2: α-Etoposide

Description:α-Etoposide, also known as etoposide or VP-16, is a chemotherapeutic agent primarily used in the treatment of various cancers, including testicular cancer and small cell lung cancer. It is derived from podophyllotoxin, a natural product obtained from the mayapple plant. The compound functions as a topoisomerase II inhibitor, interfering with DNA replication and transcription, which ultimately leads to cell death. α-Etoposide is characterized by its ability to induce apoptosis in rapidly dividing cells, making it effective against tumors. It is typically administered intravenously or orally and is known for its moderate to severe side effects, including myelosuppression, nausea, and alopecia. The compound has a relatively complex structure, featuring a sugar moiety and a phenolic group, which contribute to its biological activity. Its pharmacokinetics involve metabolism primarily in the liver, with renal excretion of metabolites. Overall, α-Etoposide remains a significant agent in oncology, with ongoing research into its efficacy and mechanisms of action.

Formula:C₂₉H₃₂O₁₃

Synonyms:
Etoposide Impurity C
alpha-Etoposide
(5S,5aR,8aR,9R)-5-[(7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
(5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-alpha-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Etoposide Impurity 3 (Etoposide EP Impurity C)
α-Etoposide
Etoposide imp C
Etoposide EP Impurity C (α-etoposide)

Found 4 products.

Product data	Purity	Price range	Estimated delivery
Etoposide EP Impurity C REF: 4Z-E-594CAS: 100007-53-2	- - -	To inquire	Mon 28 Jul 25
α-Etoposide REF: TR-E933745CAS: 100007-53-2	- - -	349.00 €~2,328.00 €	Mon 04 Aug 25
Etoposide (α/β Mixture) REF: TR-E933735CAS: 100007-53-2 260046-85-3	- - -	2,058.00 €	Thu 04 Sep 25
Etoposide EP Impurity C REF: ST-EA-CP-E31003CAS: 100007-53-2	- - -	To inquire	Fri 12 Sep 25