CAS 100007-54-3: 3',4'-dihydroxyetoposide

Description: 3',4'-Dihydroxyetoposide, with the CAS number 100007-54-3, is a derivative of etoposide, which is a well-known chemotherapeutic agent used primarily in the treatment of various cancers, including testicular cancer and lung cancer. This compound features two hydroxyl (-OH) groups at the 3' and 4' positions of its phenolic ring, which enhances its solubility and may influence its pharmacological properties. The presence of these hydroxyl groups can also affect the compound's interaction with DNA and topoisomerase II, the target enzyme for etoposide, potentially altering its efficacy and toxicity profile. 3',4'-Dihydroxyetoposide is characterized by its ability to form hydrogen bonds, which may enhance its binding affinity to biological targets. Additionally, it may exhibit antioxidant properties due to the presence of the hydroxyl groups. As a chemical entity, it is important in research settings for understanding the structure-activity relationship of etoposide derivatives and their potential therapeutic applications.

Formula: C₃₅H₃₈O₁₅

InChI: InChI=1/C29H32O13.C6H6O2/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3;7-5-3-1-2-4-6(5)8/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3;1-4,7-8H/t11-,15?,20-,21-,22+,24-,25-,26?,27-,29+;/m1./s1

Synonyms:

• 3',4'-Dihydroxy-VP 16-213
• Dhvp-16-213
• Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5-(3,4-dihydroxy-5-methoxyphenyl)-9-((4,6-O-ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-
• (5S,5aR,8aR,9R)-9-(3,4-dihydroxy-5-methoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside

3’-O-Desmethyl Etoposide

CAS: 100007-54-3

Applications An Etoposide (E933750) metabolite References Relling, M., et al.: Mol. Pharmacol., 45, 352 (1994), …

• Formula: C₂₈H₃₀O₁₃
• Color and Shape: Neat
• Molecular weight: 574.53

3’-O-Desmethyl Etoposide-d4 (~ 90%)

CAS: 100007-54-3

Applications 3’-O-Desmethyl Etoposide-d4, is the labeled analogue of 3’-O-Desmethyl Etoposide (D291970); which is an Etoposide …

• Formula: C₂₈D₄H₂₆O₁₃
• Purity: ~90%
• Color and Shape: Light Brown
• Molecular weight: 578.555

3',4'-Dihydroxyetoposide

CAS: 100007-54-3

3',4'-Dihydroxyetoposide is an anti-cancer agent that belongs to the group of epipodophyllotoxins. It inhibits DNA …

• Formula: C₂₈H₃₀O₁₃
• Purity: Min. 95%
• Molecular weight: 574.53 g/mol