CAS 10405-02-4: Trospium chloride
Description:Trospium chloride is a synthetic quaternary ammonium compound primarily used as an antimuscarinic agent for the treatment of overactive bladder. It functions by inhibiting the action of acetylcholine on muscarinic receptors in the bladder, thereby reducing involuntary contractions and increasing bladder capacity. The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its administration in clinical settings. Trospium chloride has a relatively low bioavailability due to its quaternary structure, which limits its ability to cross the blood-brain barrier, thus minimizing central nervous system side effects. Its pharmacokinetics are characterized by a rapid onset of action, with peak plasma concentrations typically occurring within a few hours after oral administration. Common side effects may include dry mouth, constipation, and urinary retention. As with any medication, it is essential to consider contraindications and potential interactions with other drugs. Overall, Trospium chloride is an effective option for managing symptoms associated with overactive bladder while maintaining a favorable safety profile.
Formula:C25H30NO3·Cl
InChI:InChI=1/C25H30NO3.ClH/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26;/h1-6,9-12,21-23,28H,7-8,13-18H2;1H/q+1;/p-1/t21-,22+,23+;
InChI key:InChIKey=RVCSYOQWLPPAOA-QKYUOBHYNA-M
SMILES:[Cl-].O=C(OC1CC2CCC(C1)[N+]32CCCC3)C(O)(C=4C=CC=CC4)C=5C=CC=CC5
- Synonyms:
- As XVII
- Azoniaspiro compound XVII
- Azoniaspiro(3α-benziloyloxynortropane-8,1'-pyrrolidine) chloride
- Benzilic acid, ester with 3α-hydroxyspiro[1α<span class="text-smallcaps">H</smallcap>,5α<smallcap>H</span>-nortropane-8,1′-pyrrolidinium] chloride
- Chlorure De Trospium
- Cloruro De Trospio
- Keptan
- Relaspium
- Sanctura
- Sanctura XR
- See more synonyms
- Spasmex
- Spasmo 3
- Spasmo-lyt
- Spiro[1α<span class="text-smallcaps">H</smallcap>,5α<smallcap>H</span>-nortropane-8,1′-pyrrolidinium], 3α-hydroxy-, chloride, benzilate
- Spiro[1αH,5αH-nortropane-8,1'-pyrrolidinium], 3α-hydroxy-, chloride, benzilate
- Spiro[8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-, chloride (1:1), (1α,3β,5α)-
- Tar 302-5018
- Trospium Chloride
- Trospiumchlorid
- Trozyd
- Spiro[8-azoniabicyclo[3.2.1]octane-8,1′-pyrrolidinium], 3-[(hydroxydiphenylacetyl)oxy]-, chloride, (1α,3β,5α)-
- Benzilic acid, ester with 3α-hydroxyspiro[1αH,5αH-nortropane-8,1′-pyrrolidinium] chloride
