CAS 1051375-10-0: Cabotegravir

Description: Cabotegravir is an antiretroviral medication primarily used in the treatment and prevention of HIV infection. It belongs to the class of drugs known as integrase strand transfer inhibitors (INSTIs), which work by inhibiting the integrase enzyme, crucial for the integration of viral DNA into the host cell's genome. This action helps prevent the replication of the virus. Cabotegravir is notable for its long-acting formulation, which can be administered via intramuscular injection, allowing for extended dosing intervals compared to daily oral medications. The substance is characterized by its high potency and specificity for the HIV integrase enzyme, contributing to its effectiveness in both treatment and pre-exposure prophylaxis (PrEP). Additionally, cabotegravir has a favorable safety profile, with common side effects including injection site reactions and mild gastrointestinal disturbances. Its development represents a significant advancement in HIV management, offering patients more flexible treatment options and improving adherence to therapy.

Formula: C₁₉H₁₇F₂N₃O₅

InChI: InChI=1S/C19H17F2N3O5/c1-9-8-29-14-7-23-6-12(16(25)17(26)15(23)19(28)24(9)14)18(27)22-5-10-2-3-11(20)4-13(10)21/h2-4,6,9,14,26H,5,7-8H2,1H3,(H,22,27)/t9-,14+/m0/s1

InChI key: InChIKey=WCWSTNLSLKSJPK-LKFCYVNXSA-N

SMILES: O=C(NCC1=CC=C(F)C=C1F)C2=CN3C(C(=O)N4C(OCC4C)C3)=C(O)C2=O

Synonyms:

• (3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
• (3s,11Ar)-n-(2,4-difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
• Cabotegravir
• Gsk 1265744A
• Gsk 744
• Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, (3S,11aR)-

Cabotegravir (GSK744, GSK1265744)

CAS: 1051375-10-0

• Formula: C₁₉H₁₇F₂N₃O₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 405.3522

Cabotegravir-d6

CAS: 1051375-10-0

• Formula: C₁₉H₁₁D₆F₂N₃O₅
• Molecular weight: 411.39

Cabotegravir

CAS: 1051375-10-0

• Formula: C₁₉H₁₇F₂N₃O₅
• Color and Shape: Off-White Solid
• Molecular weight: 405.36

Cabotegravir

CAS: 1051375-10-0

Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase …

• Formula: C₁₉H₁₇F₂N₃O₅
• Purity: 98.55% - 99.92%
• Color and Shape: Solid
• Molecular weight: 405.35

Cabotegravir

CAS: 1051375-10-0

Applications Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range …

• Formula: C₁₉H₁₇F₂N₃O₅
• Color and Shape: Off-White
• Molecular weight: 405.35

Cabotegravir-d3

CAS: 1051375-10-0

• Formula: C₁₉H₁₄D₃F₂N₃O₅
• Color and Shape: Neat
• Molecular weight: 408.37

(3S,11AR)-3-METHYL-5,7-DIOXO-2,3,5,7,11,11A-HEXAHYDROOXAZOLO[3,2-A]PYRIDO[1,2-D]PYRAZINE-8-CARBOXYLIC ACID

CAS: 1051375-10-0

• Purity: 95.0%
• Molecular weight: 264.237

Cabotegravir

CAS: 1051375-10-0

Anti-viral; HIV integrase inhibitor

• Formula: C₁₉H₁₇F₂N₃O₅
• Purity: Min. 95%
• Color and Shape: White/Off-White Solid
• Molecular weight: 405.35 g/mol