CAS 105883-79-2: corticotropin releasing hormone, biotinyl-Ser(1)-

Description:Corticotropin-releasing hormone (CRH) is a peptide hormone involved in the stress response, primarily produced in the hypothalamus. The specific variant "biotinyl-Ser(1)-" indicates that this molecule has been modified to include a biotin group attached to the serine residue at position 1, enhancing its utility in biochemical applications, such as affinity purification and detection in assays. The biotinylation allows for easy binding to avidin or streptavidin, facilitating the study of CRH's biological functions and interactions. CRH itself plays a crucial role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, stimulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, which in turn influences cortisol production from the adrenal glands. The CAS number 105883-79-2 uniquely identifies this specific compound, aiding in its recognition in scientific literature and databases. Overall, the biotinylated form of CRH is valuable for research in neuroendocrinology and stress physiology, providing insights into its mechanisms and potential therapeutic applications.