CAS 110988-86-8: 2',2'-difluorodeoxycytidine 5'-triphosphate

Description: 2',2'-Difluorodeoxycytidine 5'-triphosphate (dFdCTP) is a modified nucleoside triphosphate that serves as an important building block in nucleic acid synthesis and is particularly relevant in the context of antiviral and anticancer therapies. This compound features two fluorine atoms substituted at the 2' position of the deoxyribose sugar, which enhances its stability and alters its interaction with DNA polymerases. The presence of the triphosphate group is crucial for its role in DNA synthesis, as it provides the necessary energy for incorporation into the growing DNA strand. dFdCTP is often utilized in research and clinical settings to study DNA replication and repair mechanisms, as well as to evaluate the efficacy of nucleoside analogs in treating various diseases. Its unique structural modifications contribute to its pharmacological properties, making it a valuable tool in molecular biology and therapeutic applications.

Formula: C₉H₁₄F₂N₃O₁₃P₃

InChI: InChI=1/C9H14F2N3O13P3/c10-9(11)6(15)4(25-7(9)14-2-1-5(12)13-8(14)16)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h1-2,4,6-7,15H,3H2,(H,20,21)(H,22,23)(H2,12,13,16)(H2,17,18,19)/t4-,6-,7-/m1/s1

Synonyms:

• 2,2-DF-Ctp
• Cytidine 5'-(tetrahydrogen triphosphate), 2'-deoxy-2',2'-difluoro-
• 2'-Deoxy-2',2'-Difluorocytidine 5'-(Tetrahydrogen Triphosphate)
• 2',2'-Difluorodeoxycytidine 5'-triphosphate

Gemcitabine triphosphate

CAS: 110988-86-8

Gemcitabine triphosphate (dFdCTP), a cell metabolite, aids tumor imaging and measures drug uptake/retention.

• Formula: C₉H₁₄F₂N₃O₁₃P₃
• Color and Shape: Liquid
• Molecular weight: 503.14

Gemcitabine Triphosphate Ditriethylamine

CAS: 1035495-84-1 110988-86-8

Stability Hygroscopic, Temperature Sensitive Applications Gemcitabine Triphosphate is a phosphorylated metabolite of Gemcitabine (G305000), an …

• Formula: C₂₁H₄₄F₂N₅O₁₃P₃
• Color and Shape: Neat
• Molecular weight: 705.52

2'-Deoxy-2',2'-difluorocytidine 5'-triphosphate triethylammonium salt - Aqueous solution

CAS: 110988-86-8

2'-Deoxy-2',2'-difluorocytidine 5'-triphosphate triethylammonium salt - Aqueous solution is a triphosphate prodrug that inhibits the activity …

• Formula: C₉H₁₄F₂N₃O₁₃P₃·C₂₄H₆₀N₄
• Color and Shape: Colorless Powder
• Molecular weight: 907.9 g/mol