CAS 112297-79-7: Deoxy Arteether

Description: Deoxy Arteether is a synthetic derivative of artemisinin, primarily used in the treatment of malaria. It is characterized by its antimalarial properties, which arise from its ability to generate reactive oxygen species upon activation in the presence of heme, a component of hemoglobin. This mechanism leads to the destruction of the malaria parasite within red blood cells. Deoxy Arteether is typically administered in its ether form, which enhances its bioavailability and stability compared to other artemisinin derivatives. The compound is known for its rapid action against Plasmodium species, particularly in cases of drug-resistant malaria. Its chemical structure features a peroxide bridge, which is crucial for its pharmacological activity. Additionally, Deoxy Arteether is often evaluated for its safety profile and potential side effects, which can include gastrointestinal disturbances and neurological symptoms, although it is generally well-tolerated. Ongoing research continues to explore its efficacy and potential applications in combination therapies for malaria treatment.

Formula: C₁₇H₂₈O₄

InChI: InChI=1/C17H28O4/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17-/m1/s1

Synonyms:

• (2S,3R,3aS,6R,6aS,9S,10aR,10bR)-2-Ethoxydecahydro -3,6,9-trimethyl-0aH-9,10b-Epoxypyrano[4,3,2-jk][2]benzoxepin
• Chemal 331
• Desoxyarteether A

Deoxy Arteether

CAS: 112297-79-7

Applications A metabolite of Arteether. Artemisinin analogue; antimalarial agent. References Klayman, D., et al.: Science, …

• Formula: C₁₇H₂₈O₄
• Color and Shape: Neat
• Molecular weight: 296.40

Deoxy arteether

CAS: 112297-79-7

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• Formula: C₁₇H₂₈O₄
• Purity: Min. 95%
• Molecular weight: 296.4 g/mol