CAS 114952-97-5: 2'-O-Methyl-5-Methyluridine

Description: 2'-O-Methyl-5-Methyluridine is a modified nucleoside that features a methyl group at the 5-position of the uridine base and a methoxy group at the 2'-position of the ribose sugar. This modification enhances the stability of the nucleoside against enzymatic degradation, making it of interest in various biochemical and pharmaceutical applications. The presence of the 2'-O-methyl group can influence the nucleoside's interaction with RNA polymerases and its incorporation into RNA, potentially affecting the structure and function of RNA molecules. Additionally, 2'-O-Methyl-5-Methyluridine is often studied for its role in RNA therapeutics and as a building block in the synthesis of modified oligonucleotides. Its unique structural characteristics contribute to its potential use in research related to gene expression, RNA interference, and other molecular biology applications. The compound is typically characterized by its solubility in polar solvents and its stability under physiological conditions, making it a valuable tool in nucleic acid chemistry.

Formula: C₁₁H₁₆N₂O₆

InChI: InChI=1/C11H16N2O6/c1-5-3-13(11(17)12-9(5)16)10-8(18-2)7(15)6(4-14)19-10/h3,6-8,10,14-15H,4H2,1-2H3,(H,12,16,17)/t6-,7-,8-,10-/m1/s1

Synonyms:

• 1-[(2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
• 5-Methyl-2'-O-methyluridine
• uridine, 5-methyl-2'-O-methyl-
• 2'-O-Methyl-5-methyl-D-uridine
• 5,2'-O-Dimethyluridine

Uridine, 5-methyl-2-O-methyl- (9CI)

CAS: 114952-97-5

• Formula: C₁₁H₁₆N₂O₆
• Molecular weight: 272.2545 G/Mol

2''-O-Methyl-5-methyluridine

CAS: 114952-97-5

• Formula: C₁₁H₁₆N₂O₆
• Purity: ≥ 99.0%
• Color and Shape: White to off-white powder
• Molecular weight: 272.26