CAS 1162-60-3: -4-TIBOLONE

Description: 4-Tibolone, with the CAS number 1162-60-3, is a synthetic steroid that exhibits properties similar to both estrogen and progestin. It is primarily used in hormone replacement therapy, particularly for postmenopausal women, to alleviate symptoms such as hot flashes and to prevent osteoporosis. The compound functions as a selective tissue estrogenic activity regulator (STEAR), meaning it can exert estrogenic effects in certain tissues while acting as an anti-estrogen in others. This selective action helps to minimize some of the risks associated with traditional hormone replacement therapies. 4-Tibolone is characterized by its lipophilic nature, allowing it to be readily absorbed and distributed in the body. Its metabolism produces active metabolites that contribute to its therapeutic effects. While it is effective in managing menopausal symptoms, its use may be associated with certain risks, including potential impacts on breast tissue and cardiovascular health, necessitating careful consideration and monitoring by healthcare providers. Overall, 4-Tibolone represents a significant advancement in hormone therapy, offering a tailored approach to managing menopausal symptoms.

Formula: C₂₁H₂₈O₂

InChI: InChI=1S/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,12-13,16-19,23H,5-11H2,2-3H3/t13-,16+,17-,18+,19-,20+,21+/m1/s1

InChI key: InChIKey=WAOKMNBZWBGYIK-KIURNNQRSA-N

SMILES: O=C1C=C2CC(C)C3C(CCC4(C)C3CCC4(O)C#C)C2CC1

Synonyms:

• (7Alpha)-17-Ethynyl-17-Hydroxy-7-Methylestr-4-En-3-One
• (7a,17a)-17-Hydroxy-7-methyl-19-norpregn-4-en-20-yn-3-one
• 17-Ethynyl-17-Hydroxy-7-Methylestr-4-En-3-One
• 17a-Ethynyl-17-hydroxy-7a-methyl-4-estren-3-one
• 17β-Hydroxy-17α-ethynyl-7α-methylestr-4-en-3-one
• 19-Nor-17α-pregn-4-en-20-yn-3-one, 17-hydroxy-7α-methyl-
• 19-Norpregn-4-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7α,17α)-
• 7a-Methylnorethindrone
• 7α-Methyl-17α-ethynyl-19-nortestosterone
• Isotibolone
• Nsc 142228
• Org-OM 38
• Δ⁴-Tibolone

19-Norpregn-4-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7α,17α)-

CAS: 1162-60-3

• Formula: C₂₁H₂₈O₂
• Color and Shape: Solid
• Molecular weight: 312.4458

δ 4-Tibolone

CAS: 1162-60-3

Applications A metabolite of Tibolone. A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. …

• Formula: C₂₁H₂₈O₂
• Color and Shape: Neat
• Molecular weight: 312.45

δ4-Tibolone (1mg/ml in Acetonitrile)

CAS: 1162-60-3

• Formula: C₂₁H₂₈O₂
• Color and Shape: Single Solution
• Molecular weight: 312.45

∆4-Tibolone-13C,d3

CAS: 1162-60-3

Applications A labelled metabolite of Tibolone. A synthetic steroid with weak estrogenic, androgenic and progestogenic …

• Formula: C₂₀₁₃CH₂₅D₃O₂
• Color and Shape: Neat
• Molecular weight: 316.46

δ-4-Tibolone

CAS: 1162-60-3

Tibolone is a synthetic steroid with progesterone-like activity. It binds to the progesterone receptor, which …

• Formula: C₂₁H₂₈O₂
• Purity: Min. 95%
• Molecular weight: 312.45 g/mol