CAS 1181-54-0: clomocycline

Description: Clomocycline is a synthetic antibiotic belonging to the tetracycline class, characterized by its broad-spectrum antibacterial activity. It is primarily effective against a variety of Gram-positive and Gram-negative bacteria, making it useful in treating various infections. The compound exhibits a mechanism of action that involves inhibiting bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the translation of mRNA. Clomocycline is known for its stability in the presence of gastric acid, which enhances its bioavailability when administered orally. Additionally, it has anti-inflammatory properties, which can be beneficial in treating conditions beyond bacterial infections. However, like other tetracyclines, clomocycline may cause side effects such as gastrointestinal disturbances, photosensitivity, and potential effects on bone and teeth development in children. It is essential to use this antibiotic judiciously to minimize the risk of developing antibiotic resistance. As with any medication, it is crucial to follow appropriate dosing guidelines and consult healthcare professionals for its use in specific clinical scenarios.

Formula: C₂₃H₂₅ClN₂O₉

InChI: InChI=1S/C23H25ClN2O9/c1-22(34)8-6-9-16(26(2)3)18(30)14(21(33)25-7-27)20(32)23(9,35)19(31)12(8)17(29)13-11(28)5-4-10(24)15(13)22/h4-5,8-9,16,27-28,30-31,34-35H,6-7H2,1-3H3,(H,25,33)/t8-,9-,16-,22-,23-/m0/s1

InChI key: InChIKey=GJGDLRSSCNAKGL-KMVLDZISSA-N

SMILES: O=C(NCO)C=1C(=O)C2(O)C(O)=C3C(=O)C=4C(O)=CC=C(Cl)C4C(O)(C)C3CC2C(C1O)N(C)C

Synonyms:

• (2Z,4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-2-{hydroxy[(hydroxymethyl)amino]methylidene}-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
• (4S,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-N-(hydroxymethyl)-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-N-(hydroxymethyl)-6-methyl-1,11-dioxo-
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-N-(hydroxymethyl)-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-N-(hydroxymethyl)-6-methyl-1,11-dioxo-, [4S-(4α,4aα,5aα,6β,12aα)]-
• 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-N-(hydroxymethyl)-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
• 7-chloro-N2-(hydroxymethyl)tetracycline
• Chlormethylenecycline
• Chlortetracycline, N-methylol-
• Megachlor
• Megaclor
• N-Methylolchlorotetracycline

Clomocycline

CAS: 1181-54-0

Clomocycline

CAS: 1181-54-0

• Formula: C₂₃H₂₅ClN₂O₉
• Molecular weight: 508.91

Clomocycline

CAS: 1181-54-0

Applications Clomocycline exhibits anti-bacterial activity against chlormethylenecycline against the Micrococcus aureus, Streptococcus hemolyticus, Salmonella typhosa …

• Formula: C₂₃H₂₅ClN₂O₉
• Color and Shape: Neat
• Molecular weight: 508.906

Clomocycline

CAS: 1181-54-0

Clomocycline is a medicine that was originally used as an antibiotic and antiparasitic. It is …

• Formula: C₂₃H₂₅ClN₂O₉
• Purity: Min. 95%
• Molecular weight: 508.9 g/mol