CAS 121009-77-6: simvastatin acid

Description: Simvastatin acid, identified by the CAS number 121009-77-6, is a pharmacologically active compound derived from simvastatin, which is a member of the statin class of drugs. It primarily functions as a lipid-lowering agent, inhibiting the enzyme HMG-CoA reductase, which plays a crucial role in cholesterol biosynthesis. The compound is characterized by its ability to reduce low-density lipoprotein (LDL) cholesterol levels in the bloodstream, thereby contributing to the prevention of cardiovascular diseases. Simvastatin acid is typically administered in its lactone form, which is converted to the active acid form in the body. It exhibits good oral bioavailability and is metabolized primarily in the liver. The substance is known for its relatively low solubility in water, which can influence its absorption and bioavailability. Additionally, simvastatin acid may have various side effects, including muscle pain and liver enzyme alterations, necessitating monitoring during therapy. Overall, it is a vital therapeutic agent in managing dyslipidemia and reducing the risk of atherosclerotic cardiovascular events.

Formula: C₂₅H₄₀O₆

InChI: InChI=1/C25H40O6/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29)/t15-,16-,18+,19+,20-,21-,23-/m0/s1

Synonyms:

• Tenivastatin [INN]
• L-654969
• Simvastatin hydroxy acid
• Tenivastatin
• 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-, (1S-(1alpha(betaS*,deltaS*),2alpha,6beta,8beta,8aalpha))-
• 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-, (betaR,deltaR,1S,2S,6R,8S,8aR)-
• (3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl}-3,5-dihydroxyheptanoic acid
• Simvastatin acid

Tenivastatin

CAS: 121009-77-6

Tenivastatin (Simvastatin acid) is an anti-hyperlipidemic HMG-CoA reductase inhibitor used in the study of primary …

• Formula: C₂₅H₄₀O₆
• Purity: 99.68%
• Color and Shape: Solid
• Molecular weight: 436.58

Simvastatin Acid (Tenivastatin)

CAS: 121009-77-6

• Formula: C₂₅H₄₀O₆
• Molecular weight: 436.59

Simvastatin acid

CAS: 121009-77-6

Simvastatin acid is the active form of simvastatin, a drug used to lower blood cholesterol …

• Formula: C₂₅H₄₀O₆
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 436.58 g/mol