CAS 121250-06-4: 14-chlorodaunorubicin

Description:14-Chlorodaunorubicin is an anthracycline antibiotic and a derivative of daunorubicin, primarily used in cancer therapy. It exhibits potent antitumor activity by intercalating into DNA, thereby inhibiting topoisomerase II and disrupting DNA replication and transcription. This compound is characterized by its chlorinated structure, which enhances its cytotoxic properties compared to its parent compound. It is typically administered intravenously and is known for its effectiveness against various types of leukemia and solid tumors. However, like other anthracyclines, 14-chlorodaunorubicin is associated with significant side effects, including cardiotoxicity, myelosuppression, and potential for secondary malignancies. Its pharmacokinetics involve metabolism primarily in the liver, with excretion occurring through the bile. The compound's stability, solubility, and formulation are critical for its therapeutic efficacy and safety profile. Ongoing research continues to explore its potential in combination therapies and its mechanisms of resistance in cancer cells.

Formula:C₂₇H₂₈ClNO₁₀

InChI:InChI=1/C27H28ClNO10/c1-10-22(31)13(29)6-17(38-10)39-15-8-27(36,16(30)9-28)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,31,33,35-36H,6-9,29H2,1-2H3

Synonyms:
10-(4-amino-5-hydroxy-6-methyl-oxan-2-yl)oxy-8-(2-chloroacetyl)-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione
3-(Chloroacetyl)-3,5,12-Trihydroxy-10-Methoxy-6,11-Dioxo-1,2,3,4,6,11-Hexahydrotetracen-1-Yl 3-Amino-2,3,6-Trideoxyhexopyranoside

Found 3 products.

Product data	Purity	Price range	Estimated delivery
Doxorubicin Impurity 12 (14-Chlorodaunorubicin) REF: 4Z-D-3428CAS: 121250-06-4	- - -	To inquire	Tue 11 Mar 25
14-Chloro Daunorubicin REF: TR-C365655CAS: 121250-06-4	- - -	3,864.00 €	Mon 14 Apr 25
14-Chloro daunorubicin REF: 3D-AC19942CAS: 121250-06-4	Min. 95%	4,771.00 €	Tue 15 Apr 25