CAS 12192-57-3: Aurothioglucose
Description:Aurothioglucose is a gold-containing compound primarily used in the treatment of rheumatoid arthritis. It is classified as a gold thiol, where the gold is coordinated with a thiol group and a glucose moiety. This compound exhibits anti-inflammatory properties, which are attributed to the gold ion's ability to modulate immune responses. Aurothioglucose is typically administered via intramuscular injection and is known for its slow onset of action, often taking several weeks to achieve therapeutic effects. The compound can have side effects, including skin rashes, gastrointestinal disturbances, and potential toxicity to the kidneys and liver, necessitating regular monitoring during treatment. Its mechanism of action is not fully understood but is believed to involve the inhibition of macrophage activity and the modulation of cytokine production. As with other gold-based therapies, the use of aurothioglucose has declined with the advent of newer, more effective treatments for rheumatoid arthritis, but it remains a significant historical treatment option in the field of rheumatology.
Formula:C6H11AuO5S
InChI:InChI=1S/C6H12O5S.Au/c7-1-2-3(8)4(9)5(10)6(12)11-2;/h2-10,12H,1H2;/q;+1/p-1/t2-,3-,4+,5-,6?;/m1./s1
InChI key:InChIKey=XHVAWZZCDCWGBK-BMZZJELJSA-M
SMILES:OCC1OC2[S-][Au+][OH]C2C(O)C1O
- Synonyms:
- (<span class="text-smallcaps">D</span>-Glucopyranosylthio)gold
- (alpha-D-glucopyranosylthio)gold
- <span class="text-smallcaps">D</span>-Glucopyranose, 1-thio-, gold complex
- <span class="text-smallcaps">D</span>-Glucose, 1-thio-, S-gold deriv.
- Aureotan
- Auromyose
- Aurumine
- Authron
- Brenol
- Glucose, 1-thio-, gold salt (1:1)
- See more synonyms
- Glysanol B
- Gold
- Gold thioglucose
- Gold, (1-thio-<span class="text-smallcaps">D</span>-glucopyranosato)-
- Gold, (1-thio-<span class="text-smallcaps">D</span>-glucopyranosato-O<sup>2</sup>,S<sup>1</sup>)-
- Gold, (<span class="text-smallcaps">D</span>-glucopyranosylthio)-
- Gold, [1-(thio-κS)-<span class="text-smallcaps">D</span>-glucopyranosato-κO<sup>2</sup>]-
- Oronol
- Solganal
- Solganal B
- [1-(Thio-κS)-<span class="text-smallcaps">D</span>-glucopyranosato-κO<sup>2</sup>]gold
- Gold, (1-thio-D-glucopyranosato)-
- Gold, (1-thio-D-glucopyranosato-O2,S1)-
- D-Glucopyranose, 1-thio-, gold complex
- D-Glucose, 1-thio-, S-gold deriv.
- Gold, [1-(thio-κS)-D-glucopyranosato-κO2]-
