CAS 123155-04-4: 2,3-Di-O-methyl-6-O-tert-butyldimethylsilyl β-cyclodextrin

Description: 2,3-Di-O-methyl-6-O-tert-butyldimethylsilyl β-cyclodextrin is a modified derivative of β-cyclodextrin, a cyclic oligosaccharide composed of seven glucose units. This compound features specific functional groups that enhance its solubility and stability, making it useful in various applications, particularly in drug delivery and formulation. The presence of two methoxy groups at the 2 and 3 positions and a tert-butyldimethylsilyl group at the 6 position significantly alters its chemical properties, allowing for improved interaction with hydrophobic molecules. This modification increases the lipophilicity of the cyclodextrin, facilitating the encapsulation of poorly soluble drugs. Additionally, the bulky silyl group provides steric protection, which can enhance the stability of the compound under various conditions. The unique structure of this compound allows it to form inclusion complexes, making it valuable in pharmaceutical applications, such as enhancing the bioavailability of active pharmaceutical ingredients. Overall, 2,3-Di-O-methyl-6-O-tert-butyldimethylsilyl β-cyclodextrin is characterized by its modified solubility, stability, and ability to form complexes with various guest molecules.

Formula: C₉₈H₁₉₆O₃₅Si₇

InChI: InChI=1S/C98H196O35Si7/c1-92(2,3)134(36,37)113-50-57-64-71(99-22)78(106-29)85(120-57)128-65-58(51-114-135(38,39)93(4,5)6)122-87(80(108-31)72(65)100-23)130-67-60(53-116-137(42,43)95(10,11)12)124-89(82(110-33)74(67)102-25)132-69-62(55-118-139(46,47)97(16,17)18)126-91(84(112-35)76(69)104-27)133-70-63(56-119-140(48,49)98(19,20)21)125-90(83(111-34)77(70)105-28)131-68-61(54-117-138(44,45)96(13,14)15)123-88(81(109-32)75(68)103-26)129-66-59(52-115-136(40,41)94(7,8)9)121-86(127-64)79(107-30)73(66)101-24/h57-91H,50-56H2,1-49H3/t57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71+,72+,73+,74+,75+,76+,77+,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-/m1/s1

InChI key: InChIKey=YJLSGORJJHKFEN-CUVGCOKVSA-N

SMILES: O(C)C1C2OC(CO[Si](C)(C)C(C)(C)C)C(OC3OC(CO[Si](C)(C)C(C)(C)C)C(OC4OC(CO[Si](C)(C)C(C)(C)C)C(OC5OC(CO[Si](C)(C)C(C)(C)C)C(OC6OC(CO[Si](C)(C)C(C)(C)C)C(OC7OC(CO[Si](C)(C)C(C)(C)C)C(OC8OC(CO[Si](C)(C)C(C)(C)C)C(O2)C(OC)C8OC)C(OC)C7OC)C(OC)C6OC)C(OC)C5OC)C(OC)C4OC)C(OC)C3OC)C1OC

Synonyms:

• β-Cyclodextrin, 6A,6B,6C,6D,6E,6F,6G-heptakis-O-[(1,1-dimethylethyl)dimethylsilyl]-2A,2B,2C,2D,2E,2F,2G,3A,3B,3C,3D,3E,3F,3G-tetradeca-O-methyl-
• 6A,6B,6C,6D,6E,6F,6G-Heptakis-O-[(1,1-dimethylethyl)dimethylsilyl]-2A,2B,2C,2D,2E,2F,2G,3A,3B,3C,3D,3E,3F,3G-tetradeca-O-methyl-β-cyclodextrin
• Heptakis(6-O-tert-butyldimethylsilyl-2,3-di-O-methyl)-β-cyclodextrin
• 2,4,7,9,12,14,17,19,22,24,27,29,32,34-Tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane, β-cyclodextrin deriv.
• 2,3-Di-O-methyl-6-O-tert-butyldimethylsilyl β-cyclodextrin

Heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-b-cyclodextrin

CAS: 123155-04-4

Heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin

CAS: 123155-04-4

Applications A β-Cyclodextrin derivative. References Yan, D., et al.: Science, 303, 65 (2004), Gou, P.-F., …

• Formula: C₉₈H₁₉₆O₃₅Si₇
• Color and Shape: White
• Molecular weight: 2131.18

2,3-Dimethyl-6-tert-butyldimethylsilyl-b-cyclodextrin

CAS: 123155-04-4

This beta-cyclodextrin (β-CD) derivative is a functionalized cyclic oligosaccharide composed of seven glucose units, characterized …

• Formula: C₉₈H₁₉₆O₃₅Si₇
• Purity: Min. 95 Area-%
• Color and Shape: White Off-White Powder
• Molecular weight: 2,131.18 g/mol