Description:Endothelin-2 (ET-2) is a peptide that plays a significant role in various physiological processes, particularly in the cardiovascular system. It is part of the endothelin family, which includes endothelin-1 and endothelin-3, and is produced primarily by endothelial cells. ET-2 is known for its potent vasoconstrictive properties, meaning it can cause blood vessels to narrow, thereby influencing blood pressure and flow. The peptide is composed of 21 amino acids and is characterized by its ability to bind to specific endothelin receptors (ET_A and ET_B), which mediate its biological effects. In addition to its role in vascular regulation, endothelin-2 is involved in cellular proliferation, inflammation, and various pathophysiological conditions, including heart failure and pulmonary hypertension. Its synthesis and release can be stimulated by various factors, including hypoxia and inflammatory cytokines. Understanding the characteristics and functions of endothelin-2 is crucial for developing therapeutic strategies targeting cardiovascular diseases and other related disorders.
We use cookies to enhance your visit. We do not include advertising.
Please see our Cookies Policy for more details or adjust your preferences in "Settings".
This is the advanced settings system for our own and third-party cookies. Here you can modify parameters that will directly affect your browsing experience on this website. If you wish you may check the list of Cookie types.
Please note that disabling cookies can cause failures in the normal operation of the web.
