CAS 123622-36-6: FMOC-GLU(OBZL)-CL

Description: FMOC-GLU(OBZL)-CL, also known as FMOC-Glutamic acid (benzyl ester) chloride, is a derivative of glutamic acid that features a 9-fluorenylmethoxycarbonyl (FMOC) protective group and a benzyl ester modification. This compound is primarily utilized in peptide synthesis, particularly in the solid-phase synthesis of peptides, where it serves as a building block for the incorporation of glutamic acid residues. The FMOC group provides a stable protective mechanism for the amino group, allowing for selective deprotection under mild basic conditions, which is advantageous in multi-step synthesis. The presence of the benzyl ester enhances the lipophilicity of the molecule, which can influence solubility and reactivity during synthesis. Additionally, the chloride moiety indicates that this compound can participate in nucleophilic substitution reactions, making it versatile for further chemical modifications. Overall, FMOC-GLU(OBZL)-CL is a valuable intermediate in the field of organic and medicinal chemistry, particularly in the development of peptide-based therapeutics.

Formula: C₂₇H₂₄ClNO₅

Synonyms:

• Fmoc-L-Glutamyl Chloride Gamma-Benzyl Ester
• Fmoc-Gamma-Benzyl Ester-L-Glutamyl Chloride
• NALPHA-9-Fluorenylmethoxycarbonyl-L-glutamyl chloride GAMMA-benzyl es
• Fmoc-L-glutamyl chloride -benzyl ester

Fmoc-γ-benzyl ester-L-glutamyl chloride

CAS: 123622-36-6

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• Formula: C₂₇H₂₄NO₅Cl
• Purity: Min. 95%
• Molecular weight: 477.94 g/mol