CAS 124083-20-1: Etomoxir

Description: Etomoxir is a synthetic compound primarily known for its role as an inhibitor of carnitine palmitoyltransferase I (CPT I), an enzyme involved in the transport of long-chain fatty acids into the mitochondria for beta-oxidation. This inhibition leads to a decrease in fatty acid oxidation and an increase in glucose oxidation, making it of interest in metabolic research and potential therapeutic applications for conditions like obesity and type 2 diabetes. Chemically, Etomoxir is characterized by its unique structure, which includes a thiazolidine ring and a long hydrophobic tail, contributing to its lipophilicity. It is typically administered in research settings rather than as a clinical drug, and its effects on metabolism have been studied in various animal models. Safety and toxicity profiles are important considerations, as with any pharmacological agent, and ongoing research continues to explore its mechanisms and potential applications in metabolic disorders.

Formula: C₁₇H₂₃ClO₄

InChI: InChI=1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3/t17-/m1/s1

InChI key: InChIKey=DZLOHEOHWICNIL-QGZVFWFLSA-N

SMILES: O=C(OCC)C1(OC1)CCCCCCOC2=CC=C(Cl)C=C2

Synonyms:

• (R)-(+)-Etomoxir
• (R)-Ethyl 2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate
• 2-Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)-
• Ethyl (+)-(R)-2-(6-(p-chlorophenoxy)hexyl)glycidate
• Etomoxir [INN]
• Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)-
• Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (R)-
• Unii-Msb3Dd2Xp6
• ethyl (2R)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate
• ethyl (2S)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate
• Etomoxir

R-(+)-ETOMOXIR

CAS: 124083-20-1

• Formula: C₁₇H₂₃ClO₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 326.8151

Etomoxir-13C6

CAS: 124083-20-1

• Formula: C₁₁₁₃C₆H₂₃ClO₄
• Molecular weight: 332.77

Etomoxir-d5

CAS: 124083-20-1

• Formula: C₁₇H₁₈D₅ClO₄
• Molecular weight: 331.85

Etomoxir

CAS: 124083-20-1

• Formula: C₁₇H₂₃ClO₄
• Molecular weight: 326.82

R-(+)-Etomoxir

CAS: 124083-20-1

Applications An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of …

• Formula: C₁₇H₂₃ClO₄
• Color and Shape: Neat
• Molecular weight: 326.82

Etomoxir

CAS: 124083-20-1

Etomoxir is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that inhibits fatty acid oxidation by inhibiting …

• Formula: C₁₇H₂₃ClO₄
• Purity: 98% - 99.39%
• Color and Shape: Solid
• Molecular weight: 326.82

R-(+)-Etomoxir

CAS: 124083-20-1

Etomoxir is a potent inhibitor of the mitochondrial enzyme, fatty acid: 2-enoyl-CoA reductase. This enzyme …

• Formula: C₁₇H₂₃ClO₄
• Purity: Min. 95%
• Molecular weight: 326.81 g/mol