CAS 124412-58-4: 16-hydroxyclarithromycin

Description: 16-Hydroxyclarithromycin is a semi-synthetic derivative of the macrolide antibiotic clarithromycin, which is derived from erythromycin. This compound is characterized by the presence of a hydroxyl group at the 16th carbon position of the macrolide ring, which alters its pharmacological properties compared to its parent compound. It exhibits antibacterial activity against a range of Gram-positive and some Gram-negative bacteria, making it useful in treating various infections. The presence of the hydroxyl group enhances its solubility and may influence its bioavailability and metabolic stability. Like other macrolides, 16-hydroxyclarithromycin works by inhibiting bacterial protein synthesis, specifically by binding to the 50S ribosomal subunit. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, can vary based on the formulation and route of administration. As with other antibiotics, it is essential to use 16-hydroxyclarithromycin judiciously to prevent the development of antibiotic resistance.

Formula: C₃₈H₆₉NO₁₄

InChI: InChI=1/C38H69NO14/c1-14-26-38(9,46)30(43)22(5)27(41)19(2)16-37(8,48-13)32(53-34-28(42)25(39(10)11)15-20(3)49-34)23(6)29(24(18-40)33(45)51-26)52-35-31(44)36(7,47-12)17-21(4)50-35/h19-26,28-32,34-35,40,42-44,46H,14-18H2,1-13H3

Synonyms:

• 16-OH-Clr
• 6-{[4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-[(3-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy]-3-(hydroxymethyl)-7-methoxy-5,7,9,11,13-pentamethyloxacyclotetradecane-2,10-dione (non-preferred name)
• 16-Hydroxyclarithromycin

Clarithromycin EP Impurity A (Clarithromycin F)

CAS: 124412-58-4

• Formula: C₃₈H₆₉NO₁₄
• Molecular weight: 763.97

Clarithromycin EP Impurity A

CAS: 124412-58-4

Clarithromycin EP Impurity A is an analytical standard for clarithromycin. Clarithromycin EP Impurity A is …

• Formula: C₃₈H₆₉NO₁₄
• Purity: 90%Nmr
• Color and Shape: Powder
• Molecular weight: 763.95 g/mol