CAS 1262888-28-7: Spautin-1

Description: Spautin-1, with the CAS number 1262888-28-7, is a small organic molecule known for its role as a selective inhibitor of the autophagy process. It is primarily recognized for its ability to inhibit the activity of the deubiquitinating enzyme USP10 and USP13, which are involved in the regulation of various cellular processes, including protein degradation and cell survival. The compound has garnered interest in the field of cancer research due to its potential to enhance the efficacy of certain chemotherapeutic agents by disrupting autophagy, a mechanism that cancer cells often exploit to survive under stress. Spautin-1 is typically characterized by its moderate solubility in organic solvents and its stability under physiological conditions. Its molecular structure features specific functional groups that contribute to its biological activity, making it a valuable tool for studying autophagy and its implications in disease. As research continues, Spautin-1 may provide insights into therapeutic strategies targeting autophagy-related pathways.

Formula: C₁₅H₁₁F₂N₃

InChI: InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)

InChI key: InChIKey=AWIVHRPYFSSVOG-UHFFFAOYSA-N

SMILES: FC1=CC=C(C=C1)CNC=2N=CN=C3C=CC(F)=CC32

Synonyms:

• Spautin-1
• 6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine
• 4-((4-Fluorobenzyl)amino)-6-fluoroquinazoline
• 4-Quinazolinamine, 6-fluoro-N-[(4-fluorophenyl)methyl]-
• MBCQ deriv. C43

4-Quinazolinamine, 6-fluoro-N-[(4-fluorophenyl)methyl]-

CAS: 1262888-28-7

• Formula: C₁₅H₁₁F₂N₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 271.2647

Spautin-1

CAS: 1262888-28-7

• Formula: C₁₅H₁₁F₂N₃
• Purity: >98.0%(GC)(T)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 271.27

6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine

CAS: 1262888-28-7

• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 271.26g/mol

Spautin-1

CAS: 1262888-28-7

Spautin-1 is an autophagy inhibitor that can suppress the deubiquitination activity of ubiquitin-specific peptidase USP10 …

• Formula: C₁₅H₁₁F₂N₃
• Purity: 97.69% - 98.99%
• Color and Shape: Solid
• Molecular weight: 271.26

6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine

CAS: 1262888-28-7

• Purity: 95.0%
• Molecular weight: 271.27099609375

4-((4-Fluorobenzyl)amino)-6-fluoroquinazoline

CAS: 1262888-28-7

4-((4-Fluorobenzyl)amino)-6-fluoroquinazoline is a drug used to treat eye disorders. It has been shown to be …

• Formula: C₁₅H₁₁F₂N₃
• Purity: Min. 95%
• Molecular weight: 271.26 g/mol