CAS 129791-92-0: Rifalazil

Description: Rifalazil is a synthetic antibiotic belonging to the rifamycin class, primarily known for its antibacterial properties. It is characterized by its ability to inhibit bacterial RNA synthesis, making it effective against a range of Gram-positive and some Gram-negative bacteria. The compound is particularly noted for its activity against Mycobacterium tuberculosis, the causative agent of tuberculosis, and has been investigated for its potential use in treating various bacterial infections. Rifalazil exhibits good oral bioavailability and is metabolized in the liver, with its pharmacokinetics influenced by factors such as age and liver function. Its mechanism of action involves binding to the bacterial RNA polymerase, thereby preventing transcription. While it shows promise in clinical applications, resistance development is a concern, as with many antibiotics. Additionally, its safety profile and side effects are important considerations in therapeutic use. Overall, Rifalazil represents a significant advancement in antibiotic therapy, particularly in the context of resistant bacterial strains.

Formula: C₅₁H₆₄N₄O₁₃

InChI: InChI=1S/C51H64N4O13/c1-24(2)23-54-16-18-55(19-17-54)32-21-33(57)39-35(22-32)67-48-40(52-39)36-37-44(60)30(8)47-38(36)49(62)51(10,68-47)65-20-15-34(64-11)27(5)46(66-31(9)56)29(7)43(59)28(6)42(58)25(3)13-12-14-26(4)50(63)53-41(48)45(37)61/h12-15,20-22,24-25,27-29,34,42-43,46,57-60H,16-19,23H2,1-11H3,(H,53,63)/b13-12+,20-15-,26-14+/t25-,27+,28+,29+,34-,42-,43+,46+,51-/m0/s1

InChI key: InChIKey=UEFHFKKWYKVLDC-QEOGJXKSSA-N

SMILES: O=C(OC1C(C)C(OC)C=COC2(OC3=C(C2=O)C=4C5=NC=6C(O)=CC(=CC6OC5=C(NC(=O)C(=CC=CC(C)C(O)C(C)C(O)C1C)C)C(=O)C4C(O)=C3C)N7CCN(CC7)CC(C)C)C)C

Synonyms:

• (2S,16Z,18E,20S,21S,22R,23R,24S,25S,26S,27S,28E)-5,12,21,23-tetrahydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-1,6,15-trioxo-1,2-dihydro-6H,13H-2,7-(epoxypentadeca[1,11,13]trienoazeno)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate
• (2S,16Z,18E,20S,21S,22R,23S,24S,25S,26S,27S,28E)-5,12,21,23-tetrahydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-1,6,15-trioxo-1,2-dihydro-6H,13H-2,7-(epoxypentadeca[1,11,13]trienoazeno)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate
• 1′,4-Didehydro-1-deoxy-1,4-dihydro-3′-hydroxy-5′-[4-(2-methylpropyl)-1-piperazinyl]-1-oxorifamycin VIII
• 2,7-(Epoxypentadeca[1,11,13]trienimino)-6H-benzofuro[4,5-a]phenoxazine, rifamycin VIII deriv.
• 3'-Hydroxy-5'-(4-isobutylpiperazinyl)benzoxazinorifamycin
• 5,12-Dihydroxy-2,4-dimethyl-10-[4-(2-methyl-propyl)-l-piperazinyl]-2,7-[oxy(5-acetoxy-7,9-dihydroxy-3-methoxy-4,6,8,10,14-pentamethyl-15-oxo-l,ll,13-pentadecatriene-l,15-diyl)imino]-6H-benzofuro[4,5-a]phenoxazine-l(2H),6-dione
• Abi 1648
• Ami 1648
• Isobutylpiperazinyl rifa
• Krm 1648
• Rifamycin VIII, 1′,4-didehydro-1-deoxy-1,4-dihydro-3′-hydroxy-5′-[4-(2-methylpropyl)-1-piperazinyl]-1-oxo-
• Rifalazil

Rifalazil

CAS: 129791-92-0

Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.

• Formula: C₅₁H₆₄N₄O₁₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 941.07

Rifalazil

CAS: 129791-92-0

Applications Rifalazil has been used as a part of multi drug regimen in the treatment …

• Formula: C₅₁H₆₄N₄O₁₃
• Color and Shape: Neat
• Molecular weight: 941.073

Rifalazil

CAS: 129791-92-0

Rifalazil is a nonsteroidal anti-inflammatory drug that inhibits the activity of cyclooxygenase (COX) and lipoxygenase …

• Formula: C₅₁H₆₄N₄O₁₃
• Purity: Min. 95%
• Molecular weight: 941.07 g/mol