Description:Fmoc-L-homophenylalanine is a derivative of the amino acid homophenylalanine, characterized by the presence of a 9-fluorenylmethoxycarbonyl (Fmoc) protective group. This compound is commonly used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS), due to its ability to protect the amino group while allowing for the coupling of other amino acids. The Fmoc group is stable under basic conditions and can be removed under mild acidic conditions, facilitating the sequential addition of amino acids. Fmoc-L-homophenylalanine features a side chain that includes a phenyl group, which contributes to its hydrophobic characteristics, making it useful in the design of peptides with specific structural and functional properties. The compound is typically white to off-white in appearance and is soluble in organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). Its applications extend beyond peptide synthesis to include studies in drug design and molecular biology, where it can influence the folding and stability of peptide structures.
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