CAS 135821-54-4: Ceftizoxime alapivoxil

Description: Ceftizoxime alapivoxil is a prodrug of the cephalosporin antibiotic ceftizoxime, designed to enhance oral bioavailability. It is characterized by its ability to inhibit bacterial cell wall synthesis, making it effective against a range of Gram-positive and Gram-negative bacteria. The compound is typically administered to treat various infections, including respiratory tract infections, urinary tract infections, and skin infections. Ceftizoxime alapivoxil is known for its stability in the presence of beta-lactamases, enzymes produced by some bacteria that confer resistance to beta-lactam antibiotics. The prodrug nature of ceftizoxime alapivoxil allows for improved absorption and conversion to the active form in the body, which is crucial for its therapeutic efficacy. Its pharmacokinetic profile includes a relatively short half-life, necessitating multiple doses for sustained antibacterial activity. As with many antibiotics, potential side effects may include gastrointestinal disturbances and allergic reactions. Overall, ceftizoxime alapivoxil represents a significant advancement in the development of cephalosporin antibiotics for effective oral treatment of bacterial infections.

Formula: C₂₂H₂₈N₆O₈S₂

InChI: InChI=1/C22H28N6O8S2/c1-10(23)15(29)26-21-24-11(8-38-21)13(27-34-5)16(30)25-14-17(31)28-12(6-7-37-18(14)28)19(32)35-9-36-20(33)22(2,3)4/h6,8,10,14,18H,7,9,23H2,1-5H3,(H,25,30)(H,24,26,29)/b27-13-/t10-,14+,18+/m0/s1

Synonyms:

• [(2,2-dimethylpropanoyl)oxy]methyl (6R,7R)-7-{[(2Z)-2-[2-(L-alanylamino)-1,3-thiazol-4-yl]-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Ceftizoxime Alapivoxil

CAS: 135821-54-4

• Formula: C₂₂H₂₈N₆O₈S₂
• Color and Shape: Neat
• Molecular weight: 568.623

Ceftizoxime alapivoxil

CAS: 135821-54-4

Ceftizoxime alapivoxil is an oral prodrug of cefpodoxime proxetil that is hydrolyzed by esterases in …

• Purity: Min. 95%