CAS 140158-13-0: 4'-azidothymidine 5'-triphosphate

Description:4'-Azidothymidine 5'-triphosphate (AZT-TP) is a nucleotide analog derived from thymidine, characterized by the presence of an azido group at the 4' position of the ribose sugar. This modification enhances its potential as an antiviral agent, particularly in the treatment of HIV, as it can be incorporated into viral DNA during replication, leading to chain termination. AZT-TP is a triphosphate, which means it contains three phosphate groups, contributing to its high energy state and facilitating its role as a substrate for viral reverse transcriptase. The compound exhibits a polar nature due to the phosphate groups, making it soluble in aqueous environments, which is crucial for its biological activity. Its mechanism of action involves competitive inhibition of the reverse transcriptase enzyme, ultimately disrupting viral replication. AZT-TP is also notable for its potential side effects, as its incorporation into host DNA can lead to cytotoxicity. Overall, 4'-azidothymidine 5'-triphosphate is a significant compound in antiviral therapy, particularly in the context of HIV treatment.

Formula:C₁₀H₁₆N₅O₁₄P₃

InChI:InChI=1/C10H16N5O14P3/c1-5-3-15(9(18)12-8(5)17)7-2-6(16)10(27-7,13-14-11)4-26-31(22,23)29-32(24,25)28-30(19,20)21/h3,6-7,16H,2,4H2,1H3,(H,22,23)(H,24,25)(H,12,17,18)(H2,19,20,21)/t6-,7+,10+/m0/s1

Synonyms:
Adrt 5'-triphosphate
Adrt-TP
Thymidine 5'-(tetrahydrogen triphosphate),4'-azido-
[(2R,3S,5R)-2-azido-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl (hydroxy-phosphonooxy-phosphoryl) hydrogen phosphate

Found 3 products.

Product data	Purity	Price range	Estimated delivery
4-Azidothymidine 5-triphosphate REF: 7W-GN2897CAS: 140158-13-0	- - -	To inquire	Fri 28 Mar 25
4'-Azidothymidine 5-triphosphate REF: 3D-NA13340CAS: 140158-13-0	Min. 95%	2,856.00 €	Thu 08 May 25
4'-Azidothymidine 5'-triphosphate REF: TM-T29431CAS: 140158-13-0	- - -	1,730.00 €~2,945.00 €	Thu 29 May 25