CAS 142375-60-8: FR 139317

Description: FR 139317, with the CAS number 142375-60-8, is a chemical compound primarily recognized for its role as a selective antagonist of the neuropeptide Y (NPY) Y1 receptor. This compound is of interest in pharmacological research, particularly in the context of obesity and metabolic disorders, as it may influence appetite regulation and energy balance. FR 139317 exhibits a high degree of specificity for the Y1 receptor, making it a valuable tool for studying the physiological effects of NPY signaling. In terms of its physical properties, FR 139317 is typically characterized by its molecular structure, which includes specific functional groups that contribute to its biological activity. The compound is often evaluated in preclinical studies to assess its efficacy and safety profile. As with many research chemicals, handling and usage require adherence to safety protocols to mitigate any potential risks associated with exposure.

Formula: C₃₃H₄₄N₆O₅

InChI: InChI=1S/C33H44N6O5/c1-22(2)18-26(37-33(44)39-16-10-4-5-11-17-39)30(40)35-27(19-23-21-38(3)29-14-7-6-13-25(23)29)31(41)36-28(32(42)43)20-24-12-8-9-15-34-24/h6-9,12-15,21-22,26-28H,4-5,10-11,16-20H2,1-3H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43)/t26-,27+,28+/m0/s1

InChI key: InChIKey=LIOKMIQQPDDTNO-UPRLRBBYSA-N

SMILES: O=C(O)C(NC(=O)C(NC(=O)C(NC(=O)N1CCCCCC1)CC(C)C)CC2=CN(C=3C=CC=CC32)C)CC4=NC=CC=C4

Synonyms:

• <span class="text-smallcaps">D</smallcap>-Alanine, N-[(hexahydro-1H-azepin-1-yl)carbonyl]-<smallcap>L</smallcap>-leucyl-1-methyl-<smallcap>D</span>-tryptophyl-3-(2-pyridinyl)-
• <span class="text-smallcaps">D</smallcap>-Alanine, N-[N-[N-[(hexahydro-1H-azepin-1-yl)carbonyl]-<smallcap>L</smallcap>-leucyl]-1-methyl-<smallcap>D</span>-tryptophyl]-3-(2-pyridinyl)-
• Fr 139317
• N-(azepan-1-ylcarbonyl)-L-leucyl-1-methyl-D-tryptophyl-3-pyridin-2-yl-D-alanine
• N-[(Hexahydro-1H-azepin-1-yl)carbonyl]-<span class="text-smallcaps">L</smallcap>-leucyl-1-methyl-<smallcap>D</smallcap>-tryptophyl-3-(2-pyridinyl)-<smallcap>D</span>-alanine
• Pd 147953
• D-Alanine, N-[N-[N-[(hexahydro-1H-azepin-1-yl)carbonyl]-L-leucyl]-1-methyl-D-tryptophyl]-3-(2-pyridinyl)-
• N-[(Hexahydro-1H-azepin-1-yl)carbonyl]-L-leucyl-1-methyl-D-tryptophyl-3-(2-pyridinyl)-D-alanine
• D-Alanine, N-[(hexahydro-1H-azepin-1-yl)carbonyl]-L-leucyl-1-methyl-D-tryptophyl-3-(2-pyridinyl)-

FR 139317

CAS: 142375-60-8

• Formula: C₃₃H₄₄N₆O₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 604.7397

FR 139317

CAS: 142375-60-8

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• Formula: C₃₃H₄₄N₆O₅
• Purity: Min. 95%
• Molecular weight: 604.75 g/mol

FR 139317

CAS: 142375-60-8

highly potent and selective ETA endothelin receptor antagonist

• Formula: C₃₃H₄₄N₆O₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 604.74