CAS 144822-63-9: 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-beta-D-arabinofuranosyl]-2,4(1H,3H)-pyrimidinedione

Description: 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-beta-D-arabinofuranosyl]-2,4(1H,3H)-pyrimidinedione, with CAS number 144822-63-9, is a synthetic nucleoside analog characterized by its complex structure, which includes a pyrimidinedione core and a modified sugar moiety. This compound features a 2-deoxy-2-fluoro-beta-D-arabinofuranosyl group, which enhances its stability and bioactivity compared to natural nucleosides. The presence of the bis(4-methoxyphenyl)phenylmethyl substituent contributes to its lipophilicity, potentially influencing its pharmacokinetic properties. The compound is of interest in medicinal chemistry, particularly for its potential antiviral or anticancer activities, as modifications to nucleosides can affect their interaction with nucleic acid targets. Its unique structural features may also impact its solubility, reactivity, and binding affinity to enzymes or receptors involved in nucleic acid metabolism. Further studies are necessary to elucidate its biological activity and therapeutic potential.

Formula: C₃₀H₂₉FN₂O₇

InChI: InChI=1/C30H29FN2O7/c1-37-22-12-8-20(9-13-22)30(19-6-4-3-5-7-19,21-10-14-23(38-2)15-11-21)39-18-24-27(35)26(31)28(40-24)33-17-16-25(34)32-29(33)36/h3-17,24,26-28,35H,18H2,1-2H3,(H,32,34,36)/t24-,26+,27-,28?/m1/s1

Synonyms:

• 1-{5-O-[Bis-(4-methoxyphenyl)-phenylmethyl]-2-deoxy-2-fluoro--D-arabinofuranosyl}-2,4(1H,3H)-pyrimidinedione
• 1-[(3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-3-fluoro-4-hydroxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione

5'-O-DMT-2'-deoxy-2'-fluoro-β-D-arabinouridine

CAS: 144822-63-9

5'-O-DMT-2'-deoxy-2'-fluoro-β-D-arabinouridine is a Nucleoside Derivative - Fluoro-modified nucleoside, Protected nucleoside with NH2/OH open.

• Formula: C₃₀H₂₉FN₂O₇
• Color and Shape: Liquid
• Molecular weight: 548.56

1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil

CAS: 144822-63-9

1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil (1FdUMP) is a synthetic, modified nucleoside that is an antimetabolite. It inhibits DNA synthesis …

• Formula: C₃₀H₂₉FN₂O₇
• Purity: Min. 95%
• Color and Shape: White To Off-White Solid
• Molecular weight: 548.56 g/mol