CAS 14913-33-8: Transplatin
Description:Transplatin, with the CAS number 14913-33-8, is a platinum-based compound that is structurally similar to cisplatin, a well-known chemotherapeutic agent. However, unlike cisplatin, which has proven effective in cancer treatment, transplatin exhibits significantly lower antitumor activity. The compound is characterized by its square planar geometry, typical of platinum(II) complexes, and its ability to form coordination bonds with DNA, although its binding mode differs from that of cisplatin. Transplatin's mechanism of action involves the formation of DNA cross-links, but these cross-links are less effective in disrupting DNA replication and transcription, leading to its reduced efficacy. Additionally, transplatin has been studied for its potential to induce different cellular responses compared to cisplatin, including variations in toxicity and resistance mechanisms. Its solubility and stability in aqueous solutions are also notable, influencing its behavior in biological systems. Overall, while transplatin shares some chemical properties with cisplatin, its therapeutic potential is limited, making it primarily of interest in research contexts rather than clinical applications.
Formula:Cl2H6N2Pt
InChI:InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChI key:InChIKey=LXZZYRPGZAFOLE-UHFFFAOYSA-L
SMILES:[Cl-][Pt+2]([Cl-])([NH3])[NH3]
- Synonyms:
- (SP-4-1)-Diamminedichloroplatinum
- Diamminedichloro-Platinu(Sp-4-1)
- Dichlorodiamineplatinum(Ii)
- NSC 131558
- Nsc131558
- Platinum(2+) Chloride Ammoniate (1:2:2)
- Platinum(4+) Chloride Azanide (1:2:2)
- Platinum, diamminedichloro-, (SP-4-1)-
- Platinum, diamminedichloro-, trans-
- Trans-Diaminedichloroplatinum
- See more synonyms
- Trans-Diamminedichloroplatinum
- Trans-Dichlorodiammineplatinum
- Trans-Platinumdiamminedichloride
- Transplatin
- trans-DDP
- trans-Diamminedichloroplatinum(II)
- trans-Dichlorodiammine platinum
- trans-Dichlorodiammineplatinum(II)
- trans-Platinum(II) ammonium chloride
- trans-Platinumdiammine dichloride
