Description:4-Hydroxyflecainide is a pharmacologically active metabolite of flecainide, a class IC antiarrhythmic agent used primarily for the treatment of atrial fibrillation and other cardiac arrhythmias. This compound is characterized by its chemical structure, which includes a hydroxyl group (-OH) attached to the aromatic ring of the flecainide molecule, influencing its pharmacokinetic properties. It exhibits a similar mechanism of action to flecainide, primarily blocking sodium channels in cardiac tissues, thereby stabilizing the cardiac membrane and reducing excitability. The presence of the hydroxyl group can affect its solubility and bioavailability compared to its parent compound. 4-Hydroxyflecainide is typically studied for its role in the metabolism of flecainide and its potential contributions to the drug's overall therapeutic effects and side effects. As with many metabolites, understanding its characteristics is crucial for assessing the safety and efficacy of the parent drug in clinical settings.
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