CAS 159776-70-2: Melagatran

Description: Melagatran is a synthetic anticoagulant that functions as a direct thrombin inhibitor, primarily used in the prevention and treatment of thromboembolic disorders. It is characterized by its ability to inhibit thrombin, an enzyme crucial for blood clot formation, thereby reducing the risk of clot-related complications. Melagatran is typically administered orally and has a relatively short half-life, necessitating careful dosing and monitoring. The substance is known for its favorable pharmacokinetic profile, including predictable anticoagulant effects, which can be advantageous in clinical settings. However, its use may be associated with potential side effects, such as bleeding complications, which require vigilance during treatment. Melagatran's development was part of a broader effort to create more effective and safer anticoagulants compared to traditional therapies like warfarin. While it has shown promise in clinical trials, its availability and use may vary by region and regulatory approval status. Overall, Melagatran represents an important advancement in anticoagulant therapy, reflecting ongoing research in the field of hematology.

Formula: C₂₂H₃₁N₅O₄

InChI: InChI=1S/C22H31N5O4/c23-20(24)16-8-6-14(7-9-16)12-26-21(30)17-10-11-27(17)22(31)19(25-13-18(28)29)15-4-2-1-3-5-15/h6-9,15,17,19,25H,1-5,10-13H2,(H3,23,24)(H,26,30)(H,28,29)/t17-,19+/m0/s1

InChI key: InChIKey=DKWNMCUOEDMMIN-PKOBYXMFSA-N

SMILES: O=C(O)CNC(C(=O)N1CCC1C(=O)NCC2=CC=C(C=C2)C(=N)N)C3CCCCC3

Synonyms:

• Glycine, N-[(1R)-2-[(2S)-2-[[[[4-(aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]-
• Glycine, N-[2-[2-[[[[4-(aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]-, [S-(R*,S*)]-
• H-319/68
• N-[(1R)-2-[(2S)-2-[[[[4-(Aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]glycine
• N-[(1R)-2-{(2S)-2-[(4-carbamimidoylbenzyl)carbamoyl]azetidin-1-yl}-1-cyclohexyl-2-oxoethyl]glycine
• Melagatran

Glycine, N-[(1R)-2-[(2S)-2-[[[[4-(aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]-

CAS: 159776-70-2

• Formula: C₂₂H₃₁N₅O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 429.5126

Melagatran

CAS: 159776-70-2

• Formula: C₂₂H₃₁N₅O₄
• Molecular weight: 429.52

Melagatran-d11

CAS: 159776-70-2

• Formula: C₂₂H₂₀D₁₁N₅O₄
• Molecular weight: 440.59

Melagatran

CAS: 159776-70-2

Stability Hygroscopic Applications Synthetic thrombin inhibitor. Thrombin mutant anticoagulant antagonist. Antithrombotic. References Dewanjee, M., et …

• Formula: C₂₂H₃₁N₅O₄
• Color and Shape: Neat
• Molecular weight: 429.51

Melagatran-d11

CAS: 159776-70-2

• Formula: C₂₂D₁₁H₂₀N₅O₄
• Color and Shape: Neat
• Molecular weight: 440.58

Melagatran

CAS: 159776-70-2

Melagatran is an orally available, direct synthetic thrombin inhibitor that does not require endogenous cofactors …

• Formula: C₂₂H₃₁N₅O₄
• Purity: 100% - 98.37%
• Color and Shape: Solid
• Molecular weight: 429.51

Melagatran

CAS: 159776-70-2

Melagatran is a coumarin derivative that acts as a thrombin receptor antagonist. It has been …

• Formula: C₂₂H₃₁N₅O₄
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 429.51 g/mol