CAS 166518-60-1: Avasimibe

Description: Avasimibe is a synthetic organic compound primarily known for its role as a cholesterol-lowering agent. It functions as an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), an enzyme involved in the esterification of cholesterol, which is crucial for lipid metabolism. The inhibition of ACAT by Avasimibe leads to a reduction in cholesterol absorption and promotes the clearance of cholesterol from the bloodstream. This compound is characterized by its specific molecular structure, which includes a distinct arrangement of functional groups that contribute to its biological activity. Avasimibe has been studied for its potential therapeutic applications in managing hyperlipidemia and atherosclerosis. Additionally, it has been evaluated in various preclinical and clinical studies to assess its efficacy and safety profile. However, its development has faced challenges, and it has not been widely adopted in clinical practice. Overall, Avasimibe represents an important example of targeted pharmacological intervention in lipid metabolism.

Formula: C₂₉H₄₃NO₄S

InChI: InChI=1S/C29H43NO4S/c1-17(2)22-14-25(20(7)8)27(26(15-22)21(9)10)16-28(31)30-35(32,33)34-29-23(18(3)4)12-11-13-24(29)19(5)6/h11-15,17-21H,16H2,1-10H3,(H,30,31)

InChI key: InChIKey=PTQXTEKSNBVPQJ-UHFFFAOYSA-N

SMILES: O=C(NS(=O)(=O)OC=1C(=CC=CC1C(C)C)C(C)C)CC=2C(=CC(=CC2C(C)C)C(C)C)C(C)C

Synonyms:

• ((2,4,6-Tris(1-Methylethyl)Phenyl)Acetyl)Sulfamicacid2,6-Bis(1-Methylethyl)Phenylester
• 2,6-Di(Propan-2-Yl)Phenyl {[2,4,6-Tri(Propan-2-Yl)Phenyl]Acetyl}Sulfamate
• 2,6-Diisopropylphenyl (2-(2,4,6-triisopropylphenyl)acetyl)sulfamate
• Avasimin
• Ci 1011
• N-(2,6-Dipropan-2-Ylphenoxy)Sulfonyl-2-(2,4,6-Tripropan-2-Ylphenyl)Acetamide
• N-[(2,6-Diisopropylphenoxy)Sulfonyl]-2-(2,4,6-Triisopropylphenyl)Acetamide
• Pd 148515
• Sulfamic acid, N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester
• Sulfamic acid, [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester
• Avasimibe

Sulfamic acid, N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester

CAS: 166518-60-1

• Formula: C₂₉H₄₃NO₄S
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 501.721

Avasimibe

CAS: 166518-60-1

• Formula: C₂₉H₄₃NO₄S
• Molecular weight: 501.72

Avasimibe

CAS: 166518-60-1

• Formula: C₂₉H₄₃NO₄S
• Purity: >98.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 501.73

Avasimibe

CAS: 166518-60-1

Avasimibe (PD-148515): Oral ACAT inhibitor, prevents arterial cholesterol buildup; IC50: 3.3 μM. Hinders CYP2C9/1A2/2C19; IC50: …

• Formula: C₂₉H₄₃NO₄S
• Purity: 98.39% - 99.91%
• Color and Shape: Solid
• Molecular weight: 501.72

Avasimibe

CAS: 166518-60-1

Applications Avasimibe is a selective inhibitor of Cholesterol Acyltransferase 1 and CYP2C9. Avasimibe is known …

• Formula: C₂₉H₄₃NO₄S
• Color and Shape: White Solid
• Molecular weight: 501.72

Avasimibe

CAS: 166518-60-1

Avasimibe is a drug that inhibits the enzyme DPP-IV and prevents the degradation of DPP-IV …

• Formula: C₂₉H₄₃NO₄S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 501.72 g/mol