Description:Micafungin, also known by its developmental code FR-179642, is an echinocandin antifungal agent primarily used in the treatment of invasive fungal infections, particularly those caused by Candida and Aspergillus species. It works by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the fungal cell wall, thereby compromising the structural integrity of the fungus and leading to cell lysis. Micafungin is typically administered intravenously and is characterized by its broad-spectrum antifungal activity, low toxicity, and favorable pharmacokinetic profile. It is often utilized in immunocompromised patients, such as those undergoing chemotherapy or organ transplantation, where the risk of fungal infections is heightened. The substance is generally well-tolerated, with common side effects including infusion-related reactions and mild liver enzyme elevations. Its stability and solubility in aqueous solutions make it suitable for clinical use, and it is classified under the echinocandin class of antifungals, which are derived from fungal sources.
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