CAS 17124-23-1: 1-(5-Phospho-beta-D-arabinofuranosyl)-5-fluorouracil

Description:1-(5-Phospho-beta-D-arabinofuranosyl)-5-fluorouracil, commonly referred to as F-ara-U, is a nucleoside analog of uracil that incorporates a fluorine atom at the 5-position of the uracil ring. This compound is characterized by its unique structure, which includes a beta-D-arabinofuranosyl sugar moiety and a phosphate group, enhancing its solubility and bioavailability. F-ara-U exhibits antitumor activity, primarily through its mechanism of action as an inhibitor of RNA synthesis, leading to the disruption of nucleic acid metabolism in cancer cells. The presence of the phosphate group allows for better cellular uptake and retention, making it a potential candidate for therapeutic applications in oncology. Additionally, its structural modifications contribute to its selectivity and reduced toxicity compared to traditional chemotherapeutic agents. Overall, F-ara-U represents a significant advancement in the development of targeted cancer therapies, with ongoing research exploring its efficacy and potential combinations with other treatments.

Formula:C₉H₁₂FN₂O₉P

InChI:InChI=1/C9H12FN2O9P/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(21-8)2-20-22(17,18)19/h1,4-6,8,13-14H,2H2,(H,11,15,16)(H2,17,18,19)/t4-,5-,6+,8-/m1/s1