CAS 175463-14-6: Gemifloxacin

Description: Gemifloxacin is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity, particularly against respiratory pathogens. It is primarily used to treat respiratory tract infections, including pneumonia and bronchitis. The chemical structure of gemifloxacin features a bicyclic core with a fluorine atom, which enhances its potency and spectrum of activity. It exhibits a mechanism of action that involves the inhibition of bacterial DNA gyrase and topoisomerase IV, enzymes crucial for DNA replication and repair. Gemifloxacin is known for its favorable pharmacokinetic properties, including good oral bioavailability and a relatively long half-life, allowing for once-daily dosing. Additionally, it has a lower propensity for developing resistance compared to some other antibiotics in its class. However, like all antibiotics, it is essential to use gemifloxacin judiciously to minimize the risk of resistance development. Common side effects may include gastrointestinal disturbances and potential effects on the central nervous system. As with any medication, it is important to consider individual patient factors and potential drug interactions when prescribing gemifloxacin.

Formula: C₁₈H₂₀FN₅O₄

InChI: InChI=1/C18H20FN5O4/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27)/b22-14+

InChI key: InChIKey=ZRCVYEYHRGVLOC-HYARGMPZNA-N

SMILES: O=C(O)C1=CN(C2=NC(=C(F)C=C2C1=O)N3CC(=NOC)C(CN)C3)C4CC4

Synonyms:

• 1,8-Naphthyridine-3-carboxylic acid, 7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-
• 7-(3-Aminomethyl)-4-Methoxyimino-Pyrrolidin-1-Yl)-1-Cyclopropyl-6-Fluoro-4-Oxo-1, 4-Dihydro-[1, 8]Naphthyridine-3-Carboxylic Acid
• 7-3(Aminomethyl-4-(Z)-methoxyimino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthylridine-3-carboxylic acid
• 7-[(4E)-3-(aminomethyl)-4-(methoxyimino)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate
• 7-[(4Z)-3-(Aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• 7-[3-(Aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Mesilate
• Gemifloxacin
• Lb 20304
• Sb 265805

Gemifloxacin

CAS: 175463-14-6

Gemifloxacin is a fluoronaphthyridone with strong antibacterial effect.

• Formula: C₁₈H₂₀FN₅O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 389.38

Gemifloxacin-13C-d2

CAS: 175463-14-6

• Formula: CC₁₇H₁₈D₂FN₅O₄
• Molecular weight: 392.39

Acyl Glucuronide - Gemifloxacin

CAS: 175463-14-6

• Formula: C₂₄H₂₈FN₅O₁₀
• Color and Shape: Neat
• Molecular weight: 565.505

Gemifioxacin

CAS: 175463-14-6

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• Formula: C₁₈H₂₀FN₅O₄
• Purity: Min. 95%
• Molecular weight: 389.38 g/mol