CAS 18016-80-3: Lisuride

Description: Lisuride is a synthetic compound primarily used in the treatment of Parkinson's disease and certain types of headaches, particularly cluster headaches. It belongs to the class of drugs known as ergot alkaloids, which are derived from the ergot fungus. Lisuride acts as a dopamine agonist, meaning it stimulates dopamine receptors in the brain, which helps alleviate symptoms associated with dopamine deficiency. The substance is characterized by its ability to cross the blood-brain barrier, allowing it to exert its effects centrally. In addition to its dopaminergic activity, lisuride also exhibits properties that can influence serotonin receptors, contributing to its therapeutic effects. The compound is typically administered in oral form and has a relatively long half-life, allowing for sustained action. Side effects may include nausea, dizziness, and potential cardiovascular effects, necessitating careful monitoring during treatment. Overall, lisuride represents a valuable option in the pharmacological management of neurological disorders, particularly in patients who may not respond adequately to other treatments.

Formula: C₂₀H₂₆N₄O

InChI: InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1

InChI key: InChIKey=BKRGVLQUQGGVSM-KBXCAEBGSA-N

SMILES: O=C(NC1C=C2C=3C=CC=C4NC=C(C43)CC2N(C)C1)N(CC)CC

Synonyms:

• (+)-(5R,8S)-Lisuride
• 1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinolin-9-yl)urea
• 1,1-Diethyl-3-(<span class="text-smallcaps">D</span>-6-methylisoergolen-8-yl)urea
• 1,1-Diethyl-3-(D-6-methylisoergolen-8-yl)urea
• 3-(9,10-Didehydro-6-methylergolin-8α-yl)-1,1-diethylurea
• 9-(3,3-Diethylureido)-4,6,6a,7,8,9-hexahydro-7-methylindolo[4,3-fg]quinoline
• Ergoline, urea deriv.
• Indolo[4,3-fg]quinoline, urea deriv.
• Lisurid
• Lisurida
• Lisuride
• Lysuride
• Mesorgydine
• Methylergol carbamide
• N-(<span class="text-smallcaps">D</span>-6-Methyl-8-isoergolenyl)-N′,N′-diethylurea
• N-(D-6-Methyl-8-isoergolenyl)-N',N'-diethylurea
• N′-[(8α)-9,10-Didehydro-6-methylergolin-8-yl]-N,N-diethylurea
• Urea, 1,1-diethyl-3-(<span class="text-smallcaps">D</span>-6-methylisoergolen-8-yl)-
• Urea, 1,1-diethyl-3-(D-6-methylisoergolen-8-yl)-
• Urea, 3-(9,10-didehydro-6-methylergolin-8α-yl)-1,1-diethyl-
• Lisuridum [INN-Latin]
• Urea, N′-[(8α)-9,10-didehydro-6-methylergolin-8-yl]-N,N-diethyl-
• Lisuride [INN]
• Lisuridum
• N'-((8alpha)-9,10-Didehydro-6-methylergolin-8-yl)-N,N-diethylurea
• Urea, N'-((8alpha)-9,10-didehydro-6-methylergolin-8-yl)-N,N-diethyl-
• UNII-E0QN3D755O
• Lisurida [INN-Spanish]
• 1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea
• 3-(9,10-Didehydro-6-methylergolin-8alpha-yl)-1,1-diethylurea

Lisuride Maleate

CAS: 18016-80-3

• Formula: C₂₀H₂₆N₄O·C₄H₄O₄
• Molecular weight: 338.46 116.07

Lisuride

CAS: 18016-80-3

Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin …

• Formula: C₂₀H₂₆N₄O
• Color and Shape: Liquid
• Molecular weight: 338.45