CAS 1806-98-0: Estradiol 17β-glucuronide
Description:Estradiol 17β-glucuronide is a conjugated form of estradiol, a potent estrogen steroid hormone, and is characterized by the addition of a glucuronic acid moiety at the 17β position. This modification enhances its solubility and facilitates excretion from the body. The substance is typically found in biological fluids, such as urine, where it serves as a metabolite of estradiol. Estradiol 17β-glucuronide is known for its role in the regulation of estrogen levels and is often studied in the context of hormonal therapies and endocrine function. It exhibits lower biological activity compared to its parent compound, estradiol, but is important for understanding estrogen metabolism and pharmacokinetics. The compound is also utilized in research to investigate estrogen-related pathways and the effects of hormonal changes in various physiological and pathological conditions. Its chemical structure includes a steroid nucleus with hydroxyl groups and a glucuronide linkage, contributing to its unique properties and biological significance.
Formula:C24H32O8
InChI:InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(25)10-11(13)2-4-15(14)16(24)6-7-17(24)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1
InChI key:InChIKey=MTKNDAQYHASLID-QXYWQCSFSA-N
SMILES:O=C(O)C1OC(OC2CCC3C4CCC5=CC(O)=CC=C5C4CCC23C)C(O)C(O)C1O
- Synonyms:
- (17b)-3-hydroxyestra-1,3,5(10)-trien-17-yl b-D-glucopyranosiduronic acid
- (17β)-3-Hydroxyestra-1,3,5(10)-trien-17-yl β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid
- E<sub>2</sub>-17G
- Estradiol 17-glucuronide
- Estradiol 17β-(β-<span class="text-smallcaps">D</span>-glucuronide)
- Estradiol 17β-glucuronide
- Estradiol glucuronide
- Estrane, β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid deriv.
- Glucopyranosiduronic acid, 3-hydroxyestra-1,3,5(10)-trien-17β-yl, β-<span class="text-smallcaps">D</span>-
- OE<sub>2</sub>-17-β-<span class="text-smallcaps">D</span>-glucuronide
- See more synonyms
- b-D-glucopyranosiduronic acid, (17b)-3-hydroxyestra-1,3,5(10)-trien-17-yl
- β-<span class="text-smallcaps">D</span>-Glucopyranosiduronic acid, (17β)-3-hydroxyestra-1,3,5(10)-trien-17-yl
- Glucopyranosiduronic acid, 3-hydroxyestra-1,3,5(10)-trien-17β-yl, β-D-
- Estrane, β-D-glucopyranosiduronic acid deriv.
