CAS 18162-48-6: tert-Butyldimethylsilyl chloride
Description:Tert-Butyldimethylsilyl chloride (TBDMS chloride) is an organosilicon compound characterized by its use as a protecting group for alcohols and amines in organic synthesis. It features a tert-butyl group attached to a dimethylsilyl moiety, which enhances its stability and reactivity. The compound is typically a colorless to pale yellow liquid with a pungent odor, and it is known for its ability to form stable silyl ethers upon reaction with alcohols. TBDMS chloride is sensitive to moisture and should be handled under anhydrous conditions to prevent hydrolysis, which can lead to the formation of silyl alcohols. It is soluble in organic solvents such as dichloromethane and ether but is insoluble in water. The compound is commonly used in the synthesis of complex organic molecules, particularly in the field of medicinal chemistry and natural product synthesis, due to its effectiveness in selectively protecting functional groups during multi-step reactions. Proper safety precautions should be taken when handling TBDMS chloride, as it can be irritating to the skin and respiratory system.
Formula:C6H15ClSi
InChI:InChI=1S/C6H15ClSi/c1-6(2,3)8(4,5)7/h1-5H3
InChI key:InChIKey=BCNZYOJHNLTNEZ-UHFFFAOYSA-N
SMILES:Cl[Si](C)(C)C(C)(C)C
- Synonyms:
- (1,1-Dimethylethyl)dimethylsilyl chloride
- 2-(Chlorodimethylsilyl)-2-methylpropane
- 2-[4-(TertButyldimethylsilanyloxy)phenyl] chloride
- Chloro(1,1-dimethylethyl)dimethylsilane
- Chloro-tert-butyldimethylsilane
- Chlorodimethyl-tert-butylsilane
- Dimethyl(1,1-dimethylethyl)chlorosilane
- Dimethyl-tert-butylchlorosilane
- Dimethyl-tert-butylsilyl chloride
- Ls 1190
- See more synonyms
- Silane, T-Butyl-Dimethylchloro-
- Silane, chloro-tert-butyldimethyl-
- T-Butyldimethylchlorosilane
- TBDMS chloride
- TBDMS-Cl
- TBSCl
- Terc-Butilclorodimetilsilano
- Tert-Butyldimethylchlorosilane
- tert-Butyl(dimethyl)silane chloride
- tert-Butylchlordimethylsilan
- tert-Butylchlorodimethylsilane
- tert-Butyldimethylsilyl chloride
- (1-chloro-2-methylpropan-2-yl)(dimethyl)silane
- Silane, chloro(1,1-dimethylethyl)dimethyl-
- Tert-Butyl Dimethyl Silyl Chloride
- TBDMSCL
- Tertiary butyldimethylchlorosilane
- Tert-butyl-dimethyl chlorosilance
- Tert-Butyl Dimethylchlorosilane
- TBDMCS
![tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent]](https://static.cymitquimica.com/products/3B/thumb/B0995.jpg)
tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent]
CAS:18162-48-6
Formula:
C6H15ClSi
Purity:
>98.0%(GC)
Color and Shape:
White to Almost white powder to crystal
Molecular weight:
150.72
- Organometallic Compounds
- Organosilicon Compounds
- Silanes
- Halogenated Silanes
- See more categories
- Acids and Synthetic Reagents
- Analytical Volumetric Solutions and Indicators
- Glycoscience
- Backbone Sugars and Nucleobases
- Gas Chromatography
- Reagents for Oligosaccharide Synthesis
- Protecting Groups
- Electronic Materials
- Biochemicals and Reagents
- Salts and Derivatives of Active Pharmaceutical Ingredients (API)
Ref: 3B-B0995
| 5g | 28.00 € | ||
| 25g | 75.00 € | ||
| 100g | 180.00 € |
Estimated delivery in United States, on Thursday 20 Mar 2025
tert-Butyldimethylchlorosilane, 50% w/w in toluene
CAS:18162-48-6
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. …
Formula:
C6H15ClSi
Color and Shape:
Clear colorless, Liquid
Molecular weight:
150.72
Ref: 02-B21286
| 50g | To inquire |
Estimated delivery in United States, on Friday 21 Mar 2025
tert-Butyldimethylchlorosilane, 97%
CAS:18162-48-6
tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the …
Formula:
C6H15ClSi
Purity:
97%
Color and Shape:
Colorless to white, Crystals or powder or crystalline powder or lumps or fused solid
Molecular weight:
150.72
Ref: 02-A13064
| 5g | 41.00 € | ||
| 25g | 151.00 € | ||
| 100g | 396.00 € |
Estimated delivery in United States, on Friday 21 Mar 2025
Tert-Butyldimethylchlorosilane
CAS:18162-48-6
S03300 - tert-Butyldimethylchlorosilane
Formula:
C6H15ClSi
Purity:
98%
Color and Shape:
Solid, Solid or Crystalline Solid
Molecular weight:
150.06315469
Ref: 10-S03300
| 2g | 32.00 € | ||
| 1kg | 196.00 € | ||
| 25g | 36.00 € | ||
| 100g | 47.00 € | ||
| 250g | 101.00 € |
Estimated delivery in United States, on Tuesday 25 Mar 2025
Tert-Butyldimethylchlorosilane
CAS:18162-48-6
Formula:
C6H15ClSi
Purity:
98%
Color and Shape:
Solid
Molecular weight:
150.7218
- Organometallic Compounds
- Organosilicon Compounds
- Silanes
- Halogenated Silanes
- See more categories
- Acids and Synthetic Reagents
- Organosilicon Groups
- Organoboranes
- Analytical Volumetric Solutions and Indicators
- Glycoscience
- Backbone Sugars and Nucleobases
- Gas Chromatography
- Reagents for Oligosaccharide Synthesis
- Protecting Groups
- Organic Halides
- Electronic Materials
- Biochemicals and Reagents
- Salts and Derivatives of Active Pharmaceutical Ingredients (API)
Ref: IN-DA0035NH
| 25g | 21.00 € | ||
| 5kg | 182.00 € | ||
| 100g | 25.00 € | ||
| 10kg | 253.00 € | ||
| 500g | 41.00 € |
Estimated delivery in United States, on Thursday 27 Mar 2025
tert-Butyldimethylsilyl chloride
CAS:18162-48-6
Formula:
C6H15ClSi
Purity:
By gc: 98.6% by area (Typical Value in Batch COA)
Color and Shape:
clear. colourless crystals
Molecular weight:
150.72g/mol
Ref: 54-OR019066
| 1kg | 143.00 € | ||
| 25g | 32.00 € | ||
| 100g | 38.00 € | ||
| 500g | 96.00 € |
Estimated delivery in United States, on Friday 28 Mar 2025
tert-Butyldimethylchlorosilane
CAS:18162-48-6
Formula:
C6H15ClSi
Purity:
≥ 99.0%
Color and Shape:
White crystals
Molecular weight:
150.73
Ref: 7W-GK9215
| 25g | 58.00 € |
Estimated delivery in United States, on Friday 28 Mar 2025
tert-Butylchlorodimethylsilane, 1.0M solution in dichloromethane, AcroSeal™
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …
Formula:
C6H15ClSi
Color and Shape:
Solution, Colorless
Molecular weight:
150.72
Ref: AC-36910
| 100ml | To inquire |
Estimated delivery in United States, on Tuesday 1 Apr 2025
tert-Butylchlorodimethylsilane, 98%
CAS:18162-48-6
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …
Formula:
C6H15ClSi
Purity:
98%
Color and Shape:
Colorless to white, Crystals
Molecular weight:
150.72
Ref: AC-18393
| 5g | 38.00 € | ||
| 25g | 163.00 € | ||
| 100g | 503.00 € | ||
| 500g | 908.00 € |
Estimated delivery in United States, on Tuesday 1 Apr 2025
tert-Butyldimethylsilyl chloride, 50 wt.% solution in toluene, AcroSeal™
Controlled ProductThis Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …
Formula:
C6H15ClSi
Color and Shape:
Solution, Clear colorless
Molecular weight:
150.72
Ref: AC-43311
| 100ml | 105.00 € |
Estimated delivery in United States, on Tuesday 1 Apr 2025
tert-Butyldimethylsilyl chloride, 50% solution in toluene
CAS:18162-48-6
Color and Shape:
Colourless Liquid
Molecular weight:
150.72g/mol
Ref: 54-OR40716
| 100g | 159.00 € |
Estimated delivery in United States, on Thursday 3 Apr 2025
tert-Butyldimethylsilyl Chloride
CAS:18162-48-6
Applications Used to protect alcohols during organic synthesis. References Shen, H., et al.: J. Med. …
Formula:
C6H15ClSi
Color and Shape:
White Solid
Molecular weight:
150.72
Ref: TR-B691080
| 5g | 92.00 € | ||
| 25g | 155.00 € | ||
| 100g | 350.00 € |
Estimated delivery in United States, on Tuesday 8 Apr 2025
tert-Butyldimethylsilyl chloride
CAS:18162-48-6
Tert-butyldimethylsilyl chloride is a silicon-containing compound that is used to prepare the tert-butyl group, which …
Formula:
C6H15ClSi
Purity:
Min. 95 Area-%
Color and Shape:
Colorless Powder
Molecular weight:
150.73 g/mol
Ref: 3D-FB07718
| 1kg | 730.00 € | ||
| 2kg | 1,012.00 € | ||
| 5kg | 1,786.00 € | ||
| 250g | 350.00 € | ||
| 500g | 511.00 € |
Estimated delivery in United States, on Monday 7 Apr 2025
t-BUTYLDIMETHYLCHLOROSILANE
CAS:18162-48-6
Trialkylsilyl Blocking Agent Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, …
Formula:
C6H15ClSi
Purity:
97%
Color and Shape:
Translucent Solid
Molecular weight:
150.72
Ref: 3H-SIB1935.0
| 2kg | To inquire | ||
| 100g | To inquire | ||
| 10kg | To inquire | ||
| 100kg | To inquire |
Estimated delivery in United States, on Wednesday 9 Apr 2025
t-Butyldimethylchlorosilane, min. 97%
CAS:18162-48-6
Formula:
(CH3)3CSi(CH3)2Cl
Purity:
min. 97%
Color and Shape:
white pwdr.
Molecular weight:
150.70
Ref: 08-14-1775
| 10g | 71.00 € | ||
| 50g | 256.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
t-BUTYLDIMETHYLCHLOROSILANE, 2.85M in toluene, 48-52% solution
CAS:18162-48-6
Trialkylsilyl Blocking Agent Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, …
Formula:
C6H15ClSi
Purity:
97%
Color and Shape:
Liquid
Molecular weight:
150.72
Ref: 3H-SIB1935.5
| 2kg | Discontinued | Request information | |
| 100g | Discontinued | Request information | |
| 15kg | Discontinued | Request information | |
| 750g | Discontinued | Request information | |
| 160kg | Discontinued | Request information |
tert-Butyldimethylsilyl Chloride (TBDMS.Cl) extrapure, 98%
CAS:18162-48-6
Formula:
C6H15ClSi
Purity:
min. 98%
Color and Shape:
White, Hygroscopic compound, Clear, Colourless
Molecular weight:
150.73
Ref: SR-39227
| 25g | Discontinued | Request information | |
| 100g | Discontinued | Request information | |
| 500g | Discontinued | Request information |
