CAS 1820-81-1: 5-Chlorouracil

Description: 5-Chlorouracil is a synthetic organic compound that belongs to the class of pyrimidine derivatives. It is characterized by the presence of a chlorine atom at the 5-position of the uracil structure, which is a nucleobase found in RNA. This modification enhances its biological activity, making it a useful compound in medicinal chemistry, particularly in the development of antiviral and anticancer agents. 5-Chlorouracil exhibits properties such as being a white to off-white crystalline solid, with moderate solubility in water and organic solvents. Its mechanism of action primarily involves the inhibition of thymidylate synthase, an enzyme crucial for DNA synthesis, thereby interfering with cell proliferation. The compound is also known for its potential side effects, which can include toxicity to rapidly dividing cells. Due to its pharmacological properties, 5-Chlorouracil has been studied for its therapeutic applications, although its use is often limited by its side effects and the development of resistance in target cells.

Formula: C₄H₃ClN₂O₂

InChI: InChI=1S/C4H3ClN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChI key: InChIKey=ZFTBZKVVGZNMJR-UHFFFAOYSA-N

SMILES: O=C1NC=C(Cl)C(=O)N1

Synonyms:

• 2,4(1H,3H)-Pyrimidinedione, 5-chloro-
• 5-Chloro-2,4(1H,3H)-pyrimidinedione
• 5-Chloro-2,4-dihydroxypyrimidine
• 5-Chloro-2,4-pyrimidinedione
• 5-Chloropyrimidine-2,4-diol
• 5-chloropyrimidine-2,4(1H,3H)-dione
• Ai3-26560
• Nsc 28172
• Uracil, 5-chloro-
• Uracil, 5-chloro- (VAN)
• 5-Chlorouracil

5-Chlorouracil

CAS: 1820-81-1

• Formula: C₄H₃ClN₂O₂
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 146.53

5-Chlorouracil, 98%

CAS: 1820-81-1

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. …

• Formula: C₄H₃ClN₂O₂
• Purity: 98%
• Color and Shape: Powder, White to pale cream to pale yellow
• Molecular weight: 146.53

5-Chlorouracil

CAS: 1820-81-1

• Purity: 98.0%
• Color and Shape: Solid, White powder
• Molecular weight: 146.52999877929688

Fluorouracil Related Compound E (5-Chloropyrimidine-2,4(1H,3H)-dione)

CAS: 1820-81-1

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, …

• Formula: C₄H₃ClN₂O₂
• Color and Shape: White Off-White Powder
• Molecular weight: 145.98831

2,4(1H,3H)-Pyrimidinedione, 5-chloro-

CAS: 1820-81-1

• Formula: C₄H₃ClN₂O₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 146.5318

5-Chlorouracil

CAS: 1820-81-1

5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil .

• Formula: C₄H₃ClN₂O₂
• Color and Shape: Liquid
• Molecular weight: 146.53

5-Chlorouracil

CAS: 1820-81-1

• Formula: C₄H₃ClN₂O₂
• Molecular weight: 146.53

Fluorouracil EP Impurity E (Fluorouracil USP Related Compound E)

CAS: 1820-81-1

• Formula: C₄H₃ClN₂O₂
• Color and Shape: White To Off-White Solid
• Molecular weight: 146.53

5-Chloropyrimidine-2,4(1H,3H)-dione (5-Chlorouracil)

CAS: 1820-81-1

• Formula: C₄H₃ClN₂O₂
• Color and Shape: Neat
• Molecular weight: 146.53

5-Chlorouracil

CAS: 1820-81-1

• Purity: 98+%
• Molecular weight: 146.53g/mol

5-Chlorouracil

CAS: 1820-81-1

Impurity Fluorouracil EP Impurity E Applications Used for the experimental and clinical treatment of neoplastic …

• Formula: C₄H₃ClN₂O₂
• Color and Shape: Neat
• Molecular weight: 146.53

5-Chlorouracil

CAS: 1820-81-1

5-Chlorouracil is a drug that is used to treat cancer. It has been shown to …

• Formula: C₄H₃ClN₂O₂
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 146.53 g/mol