CAS 186953-56-0: Pafuramidine

Description: Pafuramidine, also known by its developmental code name DB289, is a synthetic compound primarily investigated for its potential as an antiprotozoal agent, particularly against infections caused by Trypanosoma brucei, the causative agent of sleeping sickness. It belongs to the class of compounds known as diamidines, which are characterized by their ability to intercalate into DNA, thereby disrupting cellular processes. Pafuramidine exhibits a favorable pharmacokinetic profile, including good oral bioavailability and tissue distribution. Its mechanism of action involves the inhibition of nucleic acid synthesis in the target organisms. The compound has shown promise in preclinical studies and clinical trials, demonstrating efficacy against various protozoan infections. Additionally, it has been noted for its relatively low toxicity in comparison to other treatments. However, as with many investigational drugs, further studies are necessary to fully understand its safety, efficacy, and potential side effects in diverse populations. Overall, pafuramidine represents a significant advancement in the search for effective treatments for neglected tropical diseases.

Formula: C₂₀H₂₀N₄O₃

InChI: InChI=1S/C20H20N4O3/c1-25-23-19(21)15-7-3-13(4-8-15)17-11-12-18(27-17)14-5-9-16(10-6-14)20(22)24-26-2/h3-12H,1-2H3,(H2,21,23)(H2,22,24)

InChI key: InChIKey=UKOQVLAXCBRRGH-UHFFFAOYSA-N

SMILES: N=C(NOC)C=1C=CC(=CC1)C=2OC(=CC2)C=3C=CC(=CC3)C(=N)NOC

Synonyms:

• 4,4′-(2,5-Furandiyl)bis[N-methoxybenzenecarboximidamide]
• Benzenecarboximidamide, 4,4′-(2,5-furandiyl)bis[N-methoxy-
• Pafuramidine
• 2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime

PAFURAMIDINE

CAS: 186953-56-0

• Formula: C₂₀H₂₀N₄O₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 364.3978

Pafuramidine

CAS: 186953-56-0

Pafuramidine (DB289) is an experimental prodrug of the metabolite DB75, an antiparasitic compound with antimalarial …

• Formula: C₂₀H₂₀N₄O₃
• Purity: 98.34%
• Color and Shape: Solid
• Molecular weight: 364.4

Pafuramidine

CAS: 186953-56-0

Applications Pafuramidine is a prodrug of Furamidine (F863600, 2HCl); a diphenylfuran compound belonging to an …

• Formula: C₂₀H₂₀N₄O₃
• Color and Shape: Neat
• Molecular weight: 364.4

Pafuramidine

CAS: 186953-56-0

Pafuramidine is a cyclic peptide that inhibits the mitochondrial membrane potential in susceptible cells. This …

• Formula: C₂₀H₂₀N₄O₃
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 364.4 g/mol