CAS 192569-17-8: 11α-Hydroxycanrenone

Description: 11α-Hydroxycanrenone is a synthetic steroid compound that is primarily recognized for its pharmacological properties as a mineralocorticoid antagonist. It is derived from canrenone, which is itself a metabolite of spironolactone. This compound exhibits a potent ability to inhibit the action of aldosterone, a hormone that regulates sodium and potassium levels in the body, making it useful in the treatment of conditions such as hypertension and heart failure. The chemical structure of 11α-Hydroxycanrenone features a hydroxyl group at the 11α position, which contributes to its biological activity. It is typically administered in a pharmaceutical form and is known for its relatively high oral bioavailability. Additionally, it may have diuretic effects, promoting the excretion of sodium and water while conserving potassium. As with many steroid derivatives, it can have side effects, including hormonal imbalances, and its use should be monitored by healthcare professionals. Overall, 11α-Hydroxycanrenone is an important compound in the field of cardiovascular pharmacotherapy.

Formula: C₂₂H₂₈O₄

InChI: InChI=1S/C22H28O4/c1-20-8-5-14(23)11-13(20)3-4-15-16-6-9-22(10-7-18(25)26-22)21(16,2)12-17(24)19(15)20/h3-4,11,15-17,19,24H,5-10,12H2,1-2H3/t15-,16-,17+,19+,20-,21-,22+/m0/s1

InChI key: InChIKey=RJTDWMKVQUPGSY-NYTLBARGSA-N

SMILES: O=C1OC2(CC1)CCC3C4C=CC5=CC(=O)CCC5(C)C4C(O)CC32C

Synonyms:

• (11A,17A)-11,17-Dihydroxy-3-Oxo-Pregna-4,6-Diene-21-Carboxylic Acid
• (11α, 17α)-11,17-Dihydroxy-3-oxo-pregna-4,6-diene-21-carboxylic acid-τ-lactone
• 11-Alpha-Hydroxy-Carnrenone
• 11-Hydroxy-Canrenone
• 11-a-Hydroxy canrenone
• 11Alpha-HydroxyCanrenone
• 11α-Hydroxycanrenone
• 3-(3-Oxo-11A,17-Dihydroxy-4,6-Diene-Pregna-17A-Yl)Propanoicacidlactone
• 3-(3-Oxo-11A,17Ss-Dihydroxy-4,6-Diene-Pregna-17A-Yl)Propanoic Acid Lactone
• Pregna-4,6-diene-21-carboxylic acid, 11,17-dihydroxy-3-oxo-, γ-lactone, (11α,17α)-
• 11α-Hydroxycanrenone(A0)

Pregna-4,6-diene-21-carboxylic acid, 11,17-dihydroxy-3-oxo-, γ-lactone, (11α,17α)-

CAS: 192569-17-8

• Formula: C₂₂H₂₈O₄
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 356.4553

Eplerenone Impurity 24

CAS: 192569-17-8

• Formula: C₂₂H₂₈O₄
• Molecular weight: 356.46

11a-Hydroxy Canrenone

CAS: 192569-17-8

Applications 11α-Hydroxy Canrenone is the key intermediate in the synthesis of Eplerenone, a cardiovascular drug. …

• Formula: C₂₂H₂₈O₄
• Color and Shape: Neat
• Molecular weight: 356.46

11-Hydroxy canrenone

CAS: 192569-17-8

11-Hydroxy canrenone is a metabolite of the drug canrenoic acid. It is an 11-hydroxylated derivative …

• Formula: C₂₂H₂₈O₄
• Purity: Min. 95%
• Molecular weight: 356.46 g/mol