CAS 19804-27-4: 4-Methyldiphenhydramine

Description: 4-Methyldiphenhydramine is an antihistamine belonging to the diphenhydramine class, primarily used for its sedative and anti-allergic properties. It is characterized by its chemical structure, which includes two phenyl rings and a methyl group attached to the nitrogen atom of the diphenhydramine backbone. This modification enhances its pharmacological effects and alters its potency and side effect profile compared to its parent compound. The substance is typically a white to off-white crystalline powder, exhibiting low solubility in water but higher solubility in organic solvents. Its mechanism of action involves antagonism of the H1 histamine receptor, which helps alleviate symptoms of allergic reactions, such as itching and runny nose. Additionally, due to its sedative effects, it is sometimes used in over-the-counter sleep aids. Safety and efficacy profiles are important considerations, as with any medication, and potential side effects may include drowsiness, dry mouth, and dizziness. As with all pharmaceuticals, proper dosage and medical guidance are essential for safe use.

Formula: C₁₈H₂₃NO

InChI: InChI=1S/C18H23NO/c1-15-9-11-17(12-10-15)18(20-14-13-19(2)3)16-7-5-4-6-8-16/h4-12,18H,13-14H2,1-3H3

InChI key: InChIKey=PJUYQWIDNIAHIZ-UHFFFAOYSA-N

SMILES: O(CCN(C)C)C(C=1C=CC=CC1)C2=CC=C(C=C2)C

Synonyms:

• 2-((p-Methyl-alpha-phenylbenzyl)oxy)ethyl(dimethyl)amine
• 4-Methyldiphenhydramine
• Ethanamine, N,N-dimethyl-2-[(4-methylphenyl)phenylmethoxy]-
• Ethylamine, N,N-dimethyl-2-[(p-methyl-α-phenylbenzyl)oxy]-
• N,N-Dimethyl-2-[(4-methylphenyl)phenylmethoxy]ethanamine
• N,N-Dimethyl-N-[2-(p-methyl-α-phenylbenzyloxy)ethyl]amine
• N,N-dimethyl-2-[(4-methylphenyl)(phenyl)methoxy]ethanamine
• Toladryl
• p-Methylbenzhydryl 2-dimethylaminoethyl ether
• p-Methyldiphenhydramine

Orphenadrine Related Compound F (N,N-Dimethyl-2-[phenyl(p-tolyl)methoxy]ethanamine citrate)

CAS: 19804-27-4

Amino-alcohols, other than those containing more than one

• Formula: C₁₈H₂₃NO·C₆H₈O₇
• Color and Shape: White Powder
• Molecular weight: 461.20497

Ethanamine, N,N-dimethyl-2-[(4-methylphenyl)phenylmethoxy]-

CAS: 19804-27-4

• Formula: C₁₈H₂₃NO
• Purity: 98%
• Color and Shape: Liquid
• Molecular weight: 269.3813

Toladryl (Diphenhydramine EP Impurity B, Dimenhydrinate EP Impurity G, Orphenadrine EP Impurity F, Orphenadrine USP Related Compound F (Free Form))

CAS: 19804-27-4

• Formula: C₁₈H₂₃NO
• Molecular weight: 269.39

Toladryl

CAS: 19804-27-4

Applications A diphenhydramine (D486900) analog classified as an antihistaminic. References Bakker, R.A. et al.: Mol. …

• Formula: C₁₈H₂₃NO
• Color and Shape: Neat
• Molecular weight: 269.38

Toladryl

CAS: 19804-27-4

Please enquire for more information about Toladryl including the price, delivery time and more detailed …

• Formula: C₁₈H₂₃NO
• Purity: Min. 95%
• Molecular weight: 269.38 g/mol

Toladryl

CAS: 19804-27-4

Toladryl is a derivative of Diphenhydramine that can cross the blood-brain barrier and exhibits oral …

• Formula: C₁₈H₂₃NO
• Color and Shape: Liquid
• Molecular weight: 269.38