CAS 2004-06-0: 6-Chloro-9-ribofuranosyl-9H-purine

Description: 6-Chloro-9-ribofuranosyl-9H-purine, commonly known as cladribine, is a synthetic purine nucleoside analog that exhibits significant biological activity. It features a ribofuranosyl sugar moiety attached to a purine base, specifically 9H-purine, with a chlorine substituent at the 6-position. This compound is primarily recognized for its role as an immunosuppressive agent, particularly in the treatment of certain hematological malignancies and autoimmune diseases. Cladribine is known to interfere with DNA synthesis and repair, leading to the selective depletion of lymphocytes, which is beneficial in conditions like multiple sclerosis. The compound is typically administered intravenously or orally, and its pharmacokinetics involve rapid distribution and metabolism. Its therapeutic efficacy is accompanied by potential side effects, including immunosuppression and increased risk of infections. Overall, 6-Chloro-9-ribofuranosyl-9H-purine is a crucial compound in modern medicine, particularly in oncology and immunology.

Formula: C₁₀H₁₁ClN₄O₄

InChI: InChI=1/C10H11ClN4O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2/t4-,6-,7-,10?/s2

InChI key: InChIKey=XHRJGHCQQPETRH-HRBNIKIZNA-N

SMILES: ClC1=NC=NC2=C1N=CN2C3OC(CO)C(O)C3O

Synonyms:

• 6-Chloro-9-ribofuranosyl-9H-purine
• 6-Chloropurine nucleoside
• 6-Chloropurine ribonucleoside
• 6-Chloropurine ribose
• 6-Chloropurine-9-¤-D-ribofuranoside
• 6-chloro-9-(beta-D-ribofuranosyl)-9H-purine
• 6-chloro-9-alpha-L-lyxofuranosyl-9H-purine
• 6-chloro-9-pentofuranosyl-9H-purine
• 9H-Purine, 6-chloro-9-ribofuranosyl-

6-Chloropurine riboside, 98%

CAS: 2004-06-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. …

• Formula: C₁₀H₁₁ClN₄O₄
• Purity: 98%
• Color and Shape: Solid, White to pale yellow
• Molecular weight: 286.67

9H-Purine, 6-chloro-9-ribofuranosyl-

CAS: 2004-06-0

• Formula: C₁₀H₁₁ClN₄O₄
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 286.6717

6-Chloropurine Riboside

CAS: 2004-06-05399-87-1

• Formula: C₁₀H₁₁ClN₄O₄
• Purity: >97.0%(T)(HPLC)
• Color and Shape: White to Orange to Green powder to crystal
• Molecular weight: 286.67

6-Chloropurine riboside

CAS: 2004-06-0

• Formula: C₁₀H₁₁ClN₄O₄
• Purity: By hplc: 97.35% (Typical Value in Batch COA)
• Color and Shape: pale yellow solid
• Molecular weight: 286.67g/mol

6-Chloropurine Riboside extrapure

CAS: 2004-06-0

• Formula: C₁₀H₁₁ClN₄O₄
• Molecular weight: 286.68